Multiple ligand-specific conformations of the β2-adrenergic receptor (Q36115098)

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11 February 2020

title

Multiple ligand-specific conformations of the β2-adrenergic receptor (English)

1 reference

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11 February 2020

1 reference

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11 February 2020

1 reference

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11 February 2020

Robert J Lefkowitz

1 reference

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11 February 2020

Jinpeng Sun

1 reference

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11 February 2020

Terrence G Oas

1 reference

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11 February 2020

Alem W Kahsai

1 reference

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11 February 2020

Kunhong Xiao

series ordinal

1 reference

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11 February 2020

Seungkirl Ahn

series ordinal

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11 February 2020

publication date

21 August 2011

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11 February 2020

published in

Nature Chemical Biology

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11 February 2020

volume

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11 February 2020

issue

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11 February 2020

page(s)

692-700

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The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

11 February 2020

cites work

1 reference

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2 October 2017

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2 October 2017

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Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.

2 October 2017

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2 October 2017

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Teaching old receptors new tricks: biasing seven-transmembrane receptors

2 October 2017

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2 October 2017

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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

2 October 2017

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Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

2 October 2017

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Crystal structure of opsin in its G-protein-interacting conformation

2 October 2017

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Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

2 October 2017

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Structural diversity of G protein-coupled receptors and significance for drug discovery

2 October 2017

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The genetic design of signaling cascades to record receptor activation

2 October 2017

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beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics

2 October 2017

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

2 October 2017

1 reference

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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

2 October 2017

1 reference

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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

2 October 2017

1 reference

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A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

2 October 2017

1 reference

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Beta-arrestin-biased ligands at seven-transmembrane receptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404607

Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors

2 October 2017

1 reference

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Seven transmembrane receptors: something old, something new.

2 October 2017

1 reference

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Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

2 October 2017

1 reference

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Mass spectrometry-based proteomics turns quantitative

2 October 2017

1 reference

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A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404607

Transduction of receptor signals by beta-arrestins

2 October 2017

1 reference

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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

2 October 2017

1 reference

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Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

2 October 2017

1 reference

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Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference

2 October 2017

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Seven-transmembrane receptors

2 October 2017

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Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.

2 October 2017

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The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals

2 October 2017

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Crystal structure of rhodopsin: A G protein-coupled receptor

2 October 2017

1 reference

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Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

2 October 2017

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A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

2 October 2017

1 reference

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A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated

2 October 2017

1 reference

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Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin

2 October 2017

1 reference

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beta-Arrestin: a protein that regulates beta-adrenergic receptor function

2 October 2017

1 reference

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Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors

2 October 2017

1 reference

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Differential signaling of the endogenous agonists at the beta2-adrenergic receptor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404607

Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells

2 July 2018

1 reference

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Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor

2 July 2018

1 reference

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Operational models of pharmacological agonism.

2 July 2018

1 reference

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Functional Selectivity and Biased Receptor Signaling

2 July 2018

1 reference

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Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

23 September 2018

1 reference

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The interaction with the cytoplasmic loops of rhodopsin plays a crucial role in arrestin activation and binding.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404607

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

23 September 2018

1 reference

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Potassium channel gating observed with site-directed mass tagging

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21857662

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21857662

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.634

1 reference

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11 February 2020

1 reference

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11 February 2020

PubMed publication ID

21857662

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21857662%20AND%20SRC:MED&resulttype=core&format=json