Matrix metalloproteinase-19 (MMP-19) also known as matrix metalloproteinase RASI is an enzyme that in humans is encoded by the MMP19 gene.[5][6]

MMP19
Identifiers
AliasesMMP19, MMP18, RASI-1, CODA, matrix metallopeptidase 19
External IDsOMIM: 601807; MGI: 1927899; HomoloGene: 1820; GeneCards: MMP19; OMA:MMP19 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001032360
NM_001272101
NM_002429
NM_022790
NM_022792

NM_001164197
NM_021412

RefSeq (protein)

NP_001259030
NP_002420

NP_001157669
NP_067387

Location (UCSC)Chr 12: 55.84 – 55.84 MbChr 10: 128.63 – 128.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is expressed in human epidermis and endothelial cells and it has a role in cellular proliferation, migration, angiogenesis and adhesion. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123342Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025355Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kolb C, Mauch S, Peter HH, Krawinkel U, Sedlacek R (Oct 1997). "The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient". Immunol Lett. 57 (1–3): 83–8. doi:10.1016/S0165-2478(97)00057-6. PMID 9232430.
  6. ^ a b "Entrez Gene: MMP19 matrix metallopeptidase 19".

Further reading

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  • The MEROPS online database for peptidases and their inhibitors: M10.021