Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation (Q33827338)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20305003%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation (English)

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21 January 2020

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21 January 2020

John H McCusker

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21 January 2020

publication date

19 March 2010

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21 January 2020

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21 January 2020

volume

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21 January 2020

issue

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21 January 2020

page(s)

729-737

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Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants

21 January 2020

cites work

1 reference

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Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin

4 July 2018

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Threonine biosynthetic genes are essential in Cryptococcus neoformans.

4 July 2018

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RNA-based 5-fluorouracil toxicity requires the pseudouridylation activity of Cbf5p.

4 July 2018

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Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast

4 July 2018

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Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo

4 July 2018

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Effect of l-Homoserine on the Growth of Mycobacterium tuberculosis

4 July 2018

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Retention and loss of amino acid biosynthetic pathways based on analysis of whole-genome sequences

4 July 2018

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4 July 2018

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A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex

4 July 2018

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Contributions of hyphae and hypha-co-regulated genes to Candida albicans virulence

4 July 2018

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FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation

4 July 2018

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Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans

4 July 2018

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A synthetic lethal screen identifies a role for the cortical actin patch/endocytosis complex in the response to nutrient deprivation in Saccharomyces cerevisiae

4 July 2018

1 reference

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Calcineurin is essential for Candida albicans survival in serum and virulence

4 July 2018

1 reference

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Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae

4 July 2018

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Parallel phenotypic analysis of sporulation and postgermination growth in Saccharomyces cerevisiae

4 July 2018

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Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance

4 July 2018

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Fungal morphogenesis and host invasion

4 July 2018

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Functional profiling of the Saccharomyces cerevisiae genome

4 July 2018

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Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents

4 July 2018

1 reference

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A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity

4 July 2018

1 reference

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Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment

4 July 2018

1 reference

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Antifungals: what's in the pipeline

4 July 2018

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Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity

4 July 2018

1 reference

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Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae

4 July 2018

1 reference

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Regulatory networks controlling Candida albicans morphogenesis

4 July 2018

1 reference

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Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization.

4 July 2018

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Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8

4 July 2018

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Threonine synthesis from homoserine as a selectable marker in mammalian cells

4 July 2018

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Comparative pathogenesis of clinical and nonclinical isolates of Saccharomyces cerevisiae

4 July 2018

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Genetic characterization of pathogenic Saccharomyces cerevisiae isolates.

4 July 2018

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New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae

4 July 2018

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Excitatory Amino Acid Transmitters

4 July 2018

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Metabolic regulation by homoserine in Escherichia coli B-r.

4 July 2018

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A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli

4 July 2018

1 reference

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Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

Overproduction of threonine by Saccharomyces cerevisiae mutants resistant to hydroxynorvaline

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

Functional characterization of the Aspergillus fumigatus calcineurin.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

Calcineurin is required for Candida albicans to survive calcium stress in serum

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

The SAT1 flipper, an optimized tool for gene disruption in Candida albicans

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

Stage-specific gene expression of Candida albicans in human blood

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

Mechanisms of interaction of Escherichia coli threonine synthase with substrates and inhibitors.

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863962

Isolation of a mutant allele that deregulates the threonine biosynthesis in Saccharomyces cerevisiae

29 October 2018

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12 December 2020

Serum stability of peptides

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12 December 2020

Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations

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12 December 2020

Evidence for distinct DNA- and RNA-based mechanisms of 5-fluorouracil cytotoxicity in Saccharomyces cerevisiae

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12 December 2020

Threonine synthase of Escherichia coli: inhibition by classical and slow-binding analogues of homoserine phosphate

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12 December 2020

Rhizocticin A, an antifungal phosphono-oligopeptide of Bacillus subtilis ATCC 6633: biological properties

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12 December 2020

Peptide stability in drug development: a comparison of peptide reactivity in different biological media

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12 December 2020

Identifiers

DOI

10.1128/EC.00045-10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20305003%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

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21 January 2020

PubMed publication ID

20305003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20305003%20AND%20SRC:MED&resulttype=core&format=json