CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76 (Q24670421)

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Nicholas G Clarkson

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Sarah Hanrahan

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Michael J Puklavec

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Martine Bomb

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A Neil Barclay

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Marion H Brown

Molecular and Cellular Biology

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language of work or name

English

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publication date

September 2006

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published in

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volume

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issue

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page(s)

6727-38

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cites work

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Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

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The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region

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Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76

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Linking the T Cell Surface Protein CD2 to the Actin-capping Protein CAPZ via CMS and CIN85

7 April 2017

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Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes

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Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A

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Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases

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The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site

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OX52 is the rat homologue of CD6: evidence for an effector function in the regulation of CD5 phosphorylation

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

7 April 2017

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Structural basis for the binding of proline-rich peptides to SH3 domains

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The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains

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Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

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Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses

28 September 2017

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The SLP-76 family of adapter proteins

28 September 2017

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Expression and characterization of a novel CD6 ligand in cells derived from joint and epithelial tissues

28 September 2017

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Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences

28 September 2017

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CD5 Inhibits Signaling at the Immunological Synapse Without Impairing Its Formation

28 September 2017

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The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells

28 September 2017

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

28 September 2017

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28 September 2017

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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

28 September 2017

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28 September 2017

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28 September 2017

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Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms

28 September 2017

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28 September 2017

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Human CD6 possesses a large, alternatively spliced cytoplasmic domain

28 September 2017

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Negative regulation of CD4 lineage development and responses by CD5.

28 September 2017

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Transgene-encoded human CD2 acts in a dominant negative fashion to modify thymocyte selection signals in mice.

30 May 2018

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Characterization of mouse CD6 with novel monoclonal antibodies which enhance the allogeneic mixed leukocyte reaction.

30 May 2018

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

30 May 2018

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Cutting edge: critical role for CD5 in experimental autoimmune encephalomyelitis: inhibition of engagement reverses disease in mice.

28 November 2018

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Frontline: Optimal T cell activation requires the engagement of CD6 and CD166.

28 November 2018

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Subunit interface residues of glutathione S-transferase A1-1 that are important in the monomer-dimer equilibrium

28 November 2018

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CD6: expression during development, apoptosis and selection of human and mouse thymocytes.

28 November 2018

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Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex

28 November 2018

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CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain

28 November 2018

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12 December 2020

Induction of negative signal through CD2 during antigen-specific T cell activation

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12 December 2020

Intracellular events involved in CD5-induced human T cell activation and proliferation

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12 December 2020

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

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12 December 2020

CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells

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12 December 2020

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

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12 December 2020