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New Impact Factor for Translational Cancer Research: 1.5

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2023 citation year: 1.5.

Translational Cancer Research 2023 CiteScore Released: 2.1

We are pleased to announce that the Translational Cancer Research (TCR) has received its 2023 CiteScore: 2.1, ranking 209 out of 333 journals in the Radiology, Nuclear Medicine and Imaging category.

Furthermore, we are delighted to highlight the remarkable achievements made by all AME journals in the CiteScore ranking.

Interviews with Outstanding Authors (2024)

In 2024, many authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspectives and insightful views as authors.

Reviewer of the Month (2024)

In 2024, TCR reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

TCR 2023 Annual Report

Greetings from the Editorial Office of TCR!

We are pleased to share the 2023 Annual Report of Translational Cancer Research. 2023 has seen much progress for TCR. We hope 2023 will bring greater things to TCR. We would like to thank you for your support and assistance in improving the journal over the past year, and we certainly look forward to your innovations and contributions in 2024.

We would especially like to express our sincere gratitude to the editorial board members, guest editors, reviewers, authors, and readers for all your support and contributions to TCR. We wish you a happy, healthy and prosperous 2024!

Ferroptosis and cuproptosis prognostic signature for prediction of prognosis, immunotherapy and drug sensitivity in hepatocellular carcinoma: development and validation based on TCGA and ICGC databases

Identification of differentially expressed genes. (A) Heatmap revealed differentially expressed genes; (B) univariate Cox regression analysis; (C) a protein-protein interaction network showing the relationship between ferroptosis-related genes and cuproptosis-related genes.

Bartholin’s gland carcinoma—the diagnostic and management challenges of a rare malignancy—a case report and review of current literature

FDG-avid right inguinal lymph node on axial CT-PET. The green arrow: FDG-avid right inguinal lymph node on axial CT-PET. FDG, fluorodeoxyglucose; CT-PET, computed tomography-positron-emission tomography.

Development of a novel angiogenesis-related lncRNA signature to predict the prognosis and immunotherapy of glioblastoma multiforme

Differences in risk scores for clinical characteristics. (A-D) The correlations between the risk score and sex, age, MGMT status, and IDH1 status were not significant (P>0.05). (E) Among the subtypes, the proneural subtypes had a significantly lower risk score than did the mesenchymal subtypes (P<0.05). **, P<0.01. IDH1, isocitrate dehydrogenase 1; MGMT, O6-methylguanine-DNA methyltransferase; ns, no significance.

Integrated analysis of single-cell and bulk transcriptome identifies a signature based on NK cell marker genes to predict prognosis and therapeutic response in clear cell renal cell carcinoma

Single-cell sequencing analysis of 20,074 cells from 7 ccRCC samples. (A) Pearson’s correlation between nFeature and nCount. (B) PCA plot colored by different samples. (C) Cells were classified into 25 clusters via UMAP algorithm. (D) Eight cell types were identified and annotated by marker genes. (E) Heatmap visualized top 5 marker genes among 8 cell clusters. (F) Visualization of gene expression in cell clusters. PC, principal component; UMAP, uniform manifold approximation and projection; NK, nature killer; ccRCC, clear cell renal cell carcinoma; PCA, principal component analysis.

Development and validation of nomograms to predict early death in non-small cell lung cancer patients with brain metastasis: a retrospective study in the SEER database

ROC curves for the nomograms of the all-cause early death and the cancer-specific early death in the training cohort (A,B) as well as in the validation cohort (C,D). ROC, receiver operating characteristic; AUC, area under the curve.

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Vol 13, No 9 (September, 2024)

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Announcement more

19th Asian Society for Neuro-Oncology (ASNO) Annual Meeting

The 19th Asian Society for Neuro-Oncology (ASNO) Annual Meeting will be held at the One Farrer Hotel, Singapore from 16 – 18 August 2024. More >>

New Impact Factor for Translational Cancer Research: 1.5

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2023 citation year: 1.5. More >>

Translational Cancer Research 2023 CiteScore Released: 2.1

We are pleased to announce that the Translational Cancer Research (TCR) has received its 2023 CiteScore: 2.1, ranking 209 out of 333 journals in the Radiology, Nuclear Medicine and... More >>

Editorial Commentary

Adjuvant treatment in resected biliary cancers: fluoropyrimidines on the spotlight

Pedro Luiz Serrano Uson Junior, Mitesh J. Borad

PDF Pages: 4510-4513 Full Text (17) Peer Review File COI Form Open Access

New insights into the impact of impaired epigenetic machinery on liver cancer malignant phenotype

Rebeca P. Marijuan, Jose J. G. Marin

PDF Pages: 4514-4519 Full Text (18) Peer Review File COI Form Open Access

Original Article

Telomere-related prognostic signature for survival assessments in lung adenocarcinoma

Hong Lin, Weiguo Yin

PDF Pages: 4520-4533 Full Text (24) Reporting Checklist Peer Review File COI Form Open Access

BUB1 as a novel marker for predicting the immunotherapy efficacy and prognosis of breast cancer

Renyu Zhou, Minting Liu, Ming Li, Yulong Peng, Xiaotan Zhang

PDF Pages: 4534-4554 Full Text (28) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Comprehensive analysis of cuproptosis-related genes involved in prognosis and tumor microenvironment infiltration of colorectal cancer

Weiyi Chen, Ke Hu, Yu Liu, Xiaocheng Li, Lijun Chen, Shaoyi Duan, Qizhang Yang

PDF Pages: 4555-4573 Full Text (21) Reporting Checklist Peer Review File COI Form Open Access

A novel gene signature based on endoplasmic reticulum stress for predicting prognosis in hepatocellular carcinoma

Xuezhi Du, Yingjie He, Penggang Dong, Caigu Yan, Yaqing Wei, Hao Yao, Jinjin Sun

PDF Pages: 4574-4592 Full Text (16) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation

Meng Wang, Zeyu Xu, Ziyang Wang, Xiaowan Xu, Yongning Sun

PDF Pages: 4593-4607 Full Text (16) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

A novel prognostic model based on telomere-related lncRNAs in gastric cancer

Xuetong Ding, Yi Zhang, Shijie You

PDF Pages: 4608-4624 Full Text (16) Reporting Checklist Peer Review File COI Form Open Access

Preparation and anticancer activity of telomerase inhibitor TAT-LPTS39 polypeptide

Xiaoying Zhang, Hui Zhang, Jian Feng, Xiaolin Tang, Mujun Zhao, Guangming Chen

PDF Pages: 4625-4638 Full Text (13) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Construction and verification of an innovative immune-related and hallmark gene sets prognostic model for bladder cancer

Xiaoliang Zhou, Yuejiao Liu, Zhihong Lv, Chong Shen, Shaobo Yang, Zhe Zhang, Ming Tan, Hailong Hu

PDF Pages: 4639-4653 Full Text (27) Reporting Checklist Peer Review File COI Form Open Access

The probability of implantation metastasis after peripheral lung cancer biopsy

Ziyao Wang, Chuyang Chen, Li Fang, Anbang Wu, Xu Li

PDF Pages: 4654-4658 Full Text (15) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Development and validation of a clinical diagnostic model for surgical site infection after surgery in patients with gastric cancer

Yiyun Peng, Yuqi Ma, Guoyuan Yang, Yalong Huang, Hao Lin, Xiaolong Ma, Yongjiang Yu, Yuntao Ma

PDF Pages: 4659-4670 Full Text (18) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Mendelian randomization study on simvastatin and gastric cancer: exploring the therapeutic potential of statins in oncology

Jiazhong Wang, Gang Cao, Yang Liu, Suo Chen, Haoyu Li, Bo Zheng

PDF Pages: 4671-4677 Full Text (18) Reporting Checklist Peer Review File COI Form Open Access

Development and validation of a nomogram to predict overall survival of gastroenteropancreatic neuroendocrine carcinoma: a SEER database analysis

Qishuang Chen, Yiying Guo, Zihan Wang, Xiaoying Chen, Chao Tian, Jiabin Zheng, Huangying Tan

PDF Pages: 4678-4693 Full Text (13) Reporting Checklist Peer Review File COI Form Open Access

Clinicopathological study of fractional exhaled nitric oxide dynamics and intratumoral inducible nitric oxide synthase expression in primary lung cancer patients

Keigo Okamoto, Yo Kawaguchi, Takuya Shiratori, Yasuhiko Oshio, Jun Hanaoka

PDF Pages: 4694-4701 Full Text (18) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Causal relationship between circulating immune cells and gastric cancer: a bidirectional Mendelian randomization analysis using UK Biobank and FinnGen datasets

Weimin Yang, Yang Ou, Hui Luo, Lijuan You, Heng Du

PDF Pages: 4702-4713 Full Text (14) Reporting Checklist Peer Review File COI Form Open Access

The m⁵C/m⁶A/m⁷G-related non-apoptotic regulatory cell death genes for the prediction of the prognosis and immune infiltration status in hepatocellular carcinoma

Xiangyu Qu, Yigang Zhang, Haoling Li, Yi Tan

PDF Pages: 4714-4735 Full Text (19) Reporting Checklist Peer Review File COI Form Open Access

Expression and prognostic impact of VDAC3 in colorectal adenocarcinoma

Kaiqiang Yang, Tao Zhu, Caixia Sheng, Jia Zhu, Jing Xu, Guoxiang Fu

PDF Pages: 4736-4751 Full Text (19) Reporting Checklist Peer Review File COI Form Open Access

Unveiling the role of KRAS in Chinese colorectal cancer patients: a positive influence on tumor mutational burden

Xuebin Wan, Xiaoni Zhang, Mingyan Xu, Zhi Zheng, Yujun Zhou, Zhiyong Zhong

PDF Pages: 4752-4762 Full Text (16) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Establishment of a nomogram for potential prediction of lung metastasis in patients with primary limb bone tumors: a study based on the SEER database

Xiao Huang, Jian-Wei Guo, Fei Han, Da-Wei Zhang

PDF Pages: 4763-4774 Full Text (15) Reporting Checklist Peer Review File COI Form Open Access

TiRNA-Gly-GCC-002 is associated with progression in patients with hepatocellular carcinoma

Lili Wu, Lijiang Zhang, Jie Cao, Yunpeng Sun, Jiajia Zhang, Liang Shi, Yong Xia

PDF Pages: 4775-4785 Full Text (16) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Construction and validation of senescence risk score signature as a novel biomarker in liver hepatocellular carcinoma: a bioinformatic analysis

Tianqi Lai, Feilong Li, Leyang Xiang, Zhilong Liu, Qiang Li, Mingrong Cao, Jian Sun, Youzhu Hu, Tongzheng Liu, Junjie Liang

PDF Pages: 4786-4799 Full Text (16) Reporting Checklist Peer Review File COI Form Open Access

Upregulation of miRNA-450b-5p targets ACTB to affect drug resistance and prognosis of ovarian cancer via the PI3K/Akt signaling pathway

Shanzhou Xie, Yuting Su, Jinyan Zhang, Fuqiang Yin, Xia Liu

PDF Pages: 4800-4812 Full Text (17) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Heterogeneity of tumor microenvironment cell groups in inflammatory and adenomatous polyposis coli mutant colorectal cancer based on single cell sequencing

Liyang Liang, Chao Zhang, Jiawang Han, Zhipeng Liu, Jinzhong Liu, Suhang Wu, Hongyu Wang

PDF Pages: 4813-4826 Full Text (12) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Prognostic biomarkers based on GUF1, EFTUD2 and GSPT1 targets affecting migration of gastric cancer cells

Haixiu Ma, Lina Suo, Jing Zhao, Ronghua Ma, Qi Wang, Jun Liu, Jinwan Qiao, Juan Wu, Juan An, Yan Liu, Yonghua Xing, Haiyan Wang, Zhanhai Su

PDF Pages: 4827-4845 Full Text (15) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Construction of a prognostic model with exosome biogenesis- and release-related genes and identification of RAB27B in immune infiltration of pancreatic cancer

Tian-Yu Li, Cheng Qin, Bang-Bo Zhao, Ze-Ru Li, Yuan-Yang Wang, Yu-Tong Zhao, Wei-Bin Wang

PDF Pages: 4846-4865 Full Text (14) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

RNA sequencing reveals transcriptomic changes in PC-12 cells following plasminogen activator, tissue type overexpression

Yongxin Mao, Chen Fang, Juping Zhao, Xin Huang, Wei He, Chenghe Wang, Fukang Sun, Jun Dai

PDF Pages: 4866-4877 Full Text (11) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Prognosis and progression of phagocytic regulatory factor-related gene combinations in clear cell renal cell carcinoma (ccRCC)

Ruihai Xiao, Zepeng Luo, Hongwei Huang, Yingqun Yin

PDF Pages: 4878-4895 Full Text (21) Reporting Checklist Peer Review File COI Form Open Access

Tumor-derived exosomal miR-103a-3p promotes vascular permeability and proliferation by targeting ZO-1 and ACOX-1 in nasopharyngeal carcinoma

Ying Shan, Hongmei Fan, Linlin Chai, Xiuzhi Kong, Haijuan Xiao, Mengdie You, Yiwen You

PDF Pages: 4896-4912 Full Text (14) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Long non-coding RNA LINC-PINT is associated with favorable prognosis in cancer patients: a systematic review and meta-analysis

Nayoung Han, Hyun Min Koh

PDF Pages: 4913-4922 Full Text (13) Reporting Checklist Peer Review File COI Form Open Access

The LINC00957/miR-17-5p axis regulates the cell cycle and migration in glioblastoma via the cuproptosis-related gene nephronectin

Renhua Duan, Xiangmao Zhao, Zejiang Hong, Lisheng Yu

PDF Pages: 4923-4937 Full Text (18) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Unveiling the atlas of associations between 1,400 plasma metabolites and 24 tumors: Mendelian randomization analyses

Jili Zhang, Zhibin Hao, Zewei Chen, Xingxing Su, Wentao Xu, Xin Jiang, Xinwen Nian

PDF Pages: 4938-4956 Full Text (11) Reporting Checklist Peer Review File COI Form Open Access

Prognostic value of PLEKHA4 and its correlation with tumor-infiltrating immune cells in breast cancer: a comprehensive study based on bioinformatics and clinical analysis validation

Liu Li, Zewen Feng, Ye Zhao, Boan Lai, Qingxin Zhang, Zhongtang Xiong, Wei Zhang

PDF Pages: 4957-4972 Full Text (15) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Development and validation of a recurrence risk assessment model for high-grade bladder cancer based on TCGA and GEO

Hongxin Wang, Yuping Zheng, Cheng Zhang, Mingshan Li

PDF Pages: 4973-4984 Full Text (15) Reporting Checklist Peer Review File COI Form Open Access

TGF-β signaling-related signature for predicting prognosis and therapeutic response in lower-grade glioma

Jian Yan, Xingwang Zhou, Hua Yang

PDF Pages: 4985-5002 Full Text (15) Reporting Checklist Peer Review File COI Form Open Access

Analysis of the role of POC1A in the development and progression of hepatocellular carcinoma

Hongrui Zhou, Mengxue Zhang, Xin Zhang, Xintong Du, Huihui Cao, Xiuli Bi

PDF Pages: 5003-5020 Full Text (19) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

The role of IQCB1 in liver cancer: a bioinformatics analysis

Dongmei Han, Bin Ling, Caihong Wu, Hao Jin

PDF Pages: 5021-5036 Full Text (17) Reporting Checklist Peer Review File COI Form Open Access

The surgical, histopathological characteristics, and survival outcome of ovarian clear cell carcinoma: a retrospective case series sharing the experience of a tertiary cancer centre

Sally El Tawab, Sabina Nistor, Rene Roux, Sanjiv Manek, Kezia Gaitskell, Ahmed Ashour Ahmed, Sean Kehoe, Hooman Soleymani majd

PDF Pages: 5037-5049 Full Text (14) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Comparison of surgical margins and adjuvant therapy for head and neck cancer by hospital type

Douglas R. Farquhar, Nicholas R. Lenze, Jason Tasoulas, Siddharth Sheth, Jose P. Zevallos, Catherine Lumley, Jeffrey Blumberg, Samip Patel, Trevor Hackman, Mark C. Weissler, Wendell G. Yarbrough, Andrew F. Olshan, Adam M. Zanation

PDF Pages: 5050-5063 Full Text (14) Reporting Checklist Peer Review File COI Form Open Access

Disulfidptosis-related gene SLC7A11 predicts prognosis and indicates tumor immune infiltration in lung adenocarcinoma

Jing Zhu, Hui Ge, Yinsong Chen, She Zhang, Junjie Wu, Weiping Nai, Lingfeng Min

PDF Pages: 5064-5072 Full Text (19) Reporting Checklist Peer Review File COI Form Open Access

TCF4 as a potential prognostic biomarker and an anticancer target in gastric cancer

Hailong Wang, Arvind Sahu, Michael D. Chuong, Ruiping Li

PDF Pages: 5073-5086 Full Text (18) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Bioinformatics study of bortezomib resistance-related proteins and signaling pathways in mantle cell lymphoma

Linyi Zheng, Qian Shen, Guanghong Fang, Ian J. Robertson, Qiqiang Long

PDF Pages: 5087-5096 Full Text (19) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

GLYAT suppresses liver cancer and clear cell renal cell carcinoma progression by downregulating ROCK1 expression

Yechen Xia, Wentao Huang, Guang-Zhi Jin

PDF Pages: 5097-5111 Full Text (13) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Review Article

Narrative review of research progress of RNA m⁵C methylation in head and neck malignancies

Lang Cheng, Chengtao Wang, Dan Zhao, Shuangjiang Wu

PDF Pages: 5112-5122 Full Text (13) Reporting Checklist Peer Review File COI Form Open Access

Strategies and influencing factors for the treatment of advanced non-small cell lung cancer based on epidermal growth factor receptor tyrosine kinase inhibitors: a narrative review

Linwu Kuang, Peng Wang, Lin Zhou, Yangkai Li

PDF Pages: 5123-5140 Full Text (22) Reporting Checklist Peer Review File COI Form Open Access

Case Report

A case report of robot-assisted radical nephrectomy and inferior vena cava thrombectomy in a patient with renal cell carcinoma after pembrolizumab and axitinib combination therapy

Ryo Shiode, Terutaka Noda, Shota Nobumori, Naoya Sugihara, Maki Yamakawa, Kaori Saiki, Takatora Sawada, Reina Kono, Toshio Kakuda, Kenichi Nishimura, Tetsuya Fukumoto, Noriyoshi Miura, Yuki Miyauchi, Tadahiko Kikugawa, Takashi Saika

PDF Pages: 5141-5148 Full Text (24) Reporting Checklist Peer Review File COI Form Open Access

Visual impairment as the initial presentation in multiple myeloma: a case report and literature review

Zhijian Xu, Song Yang, Lina Zhu, Xing Wan, Hu Xu, Huahui Chen, Lude Wang, Minfeng Tong, Qi Tu

PDF Pages: 5149-5156 Full Text (13) Reporting Checklist Peer Review File COI Form Open Access

Erratum

Erratum to MicroRNA-106a suppresses prostate cancer proliferation, migration and invasion by targeting tumor-derived IL-8

Editorial Office

PDF Pages: 5157-5158 Full Text (14) Open Access

Erratum to reduction of Hip2 suppresses gastric cancer cell proliferation, migration, invasion and tumorigenesis

Editorial Office

PDF Pages: 5159-5160 Full Text (14) Open Access

Retraction

Retraction: WSB2 as a target of Hedgehog signaling promoted the malignantbiological behavior of Xuanwei lung cancer through regulating Wnt/β-catenin signaling

Xueqiang Wei, Jun Liao, Yujie Lei, Minjie Li, Guangqiang Zhao, Yongchun Zhou, Lianhua Ye, Yunchao Huang

PDF Pages: 5161 Full Text (15) COI Form Open Access

Review Article

The management of brain necrosis as a result of SRS treatment for intra-cranial tumors

Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen

Published online: 28 August 2014

PDF Pages: 373-382 Full Text (124448) COI Form Open Access

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis

Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Published online: 05 March 2013

PDF Pages: 25-32 Full Text (76045) COI Form Open Access

Review Article

Common applications of next-generation sequencing technologies in genomic research

Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Published online: 05 March 2013

PDF Pages: 33-45 Full Text (65448) COI Form Open Access

Biological basis of IORT

Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects

Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara

Published online: 25 February 2014

PDF Pages: 18-31 Full Text (47571) COI Form Open Access

Review Articles

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer

Rositsa Dueva, George Iliakis

Published online: 19 June 2013

PDF Pages: 163-177 Full Text (45801) COI Form Open Access

Review Articles

Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer

Deep Kwatra, Anand Venugopal, Shrikant Anant

Published online: 26 September 2013

PDF Pages: 330-342 Full Text (44366) COI Form Open Access

Editorial

Morphine, when used for treating patients with acute pancreatitis, could be more risky than previously suspected

Juan Iovanna, Maria Cecilia Mallmann

Published online: 24 October 2017

PDF Pages: S1166-S1168 Full Text (42186) COI Form Open Access

Original Article

Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review

Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi

Published online: 28 April 2017

PDF Pages: 354-365 Full Text (41807) COI Form Open Access

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Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

Published online: 26 September 2013

PDF Pages: 309-319 Full Text (36987) COI Form Open Access

Review Article

EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients

Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell

Published online: 19 January 2019

PDF Pages: S23-S47 Full Text (36823) COI Form Open Access

Biological basis of IORT

Cell and molecular response to IORT treatment

Luigi Minafra, Valentina Bravatà

Published online: 25 February 2014

PDF Pages: 32-47 Full Text (35385) COI Form Open Access

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Cancer biomarker discovery and validation

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Published online: 18 June 2015

PDF Pages: 256-269 Full Text (34874) COI Form Open Access

Editorial

The CROSS road in neoadjuvant therapy for esophageal cancer: long-term results of CROSS trial

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Published online: 29 September 2016

PDF Pages: S415-S419 Full Text (29660) COI Form Open Access

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Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review

Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin

Published online: 30 December 2018

PDF Pages: 1743-1747 Full Text (28445) COI Form Open Access

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DNA damage tolerance: a double-edged sword guarding the genome

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Published online: 19 June 2013

PDF Pages: 107-129 Full Text (28383) COI Form Open Access

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DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Published online: 19 June 2013

PDF Pages: 144-154 Full Text (28099) COI Form Open Access

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Intraoperative radiotherapy in locally-advanced and recurrent rectal cancer: retrospective review of 68 cases

Sergey Potemin, Ivan Uvarov, Igor Vasilenko

Published online: 26 April 2015

PDF Pages: 189-195 Full Text (27653) COI Form Open Access

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EGFR and HER2: is there a role in ovarian cancer?

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Published online: 13 February 2015

PDF Pages: 107-117 Full Text (26711) COI Form Open Access

Review Article on Endometrial Cancer

Current role of Pipelle endometrial sampling in early diagnosis of endometrial cancer

Milan Milosav Terzic, Gulzhanat Aimagambetova, Sanja Terzic, Melanie Norton, Gauri Bapayeva, Simone Garzon

Published online: 23 December 2020

PDF Pages: 7716-7724 Full Text (26483) COI Form Open Access

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Robert J. Lutz

Published online: 13 February 2015

PDF Pages: 118-126 Full Text (26217) Open Access

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The IGF-1R/AKT pathway determines cell fate in response to p53

Lei Duan, Carl G. Maki

Intra molecular interactions in the regulation of p53 pathway

Jiandong Chen

TP53 mutations in epithelial ovarian cancer

Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu

Modulation of the p53 family network by RNA-binding proteins

Chris Lucchesi, Jin Zhang, Xinbin Chen

Radiomics in head and neck cancer: from exploration to application

Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller

Prostate cancer radiomics and the promise of radiogenomics

Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack

Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies

Wei Lu, Wengen Chen

The emerging field of radiomics in esophageal cancer: current evidence and future potential

Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin

Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire

Jung H. Suh, Julie D. Saba

Computational methods and opportunities for phosphorylation network medicine

Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury

M. Kerry O’Banion

Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic

Naomi Lomeli, Daniela A. Bota

Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma

David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright

New light on the pancreatic cyst conundrum

Nathan A. Berger

HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?

Andrew J. Scott, John C. Wilkinson

Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts

Kristopher A. Lyon, Jason H. Huang

Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4

Nan Ding, Qianzheng Zhu

Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?

Apar Gupta, Nisha Ohri, Bruce G. Haffty

Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents

Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi

CRISPR-based genetic interaction maps inform therapeutic strategies in cancer

Poornima Ramkumar, Martin Kampmann

Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study

Melin J. Khandekar, Rakesh Jain

The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin

Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed

Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer

Joanne P. Young, Timothy J. Price, Susan Parry

Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response

R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang

Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes

Theresa L. Whiteside

TIC10/ONC201—a potential therapeutic in glioblastoma

Georg Karpel-Massler, Markus D. Siegelin

IDH mutational status and the immune system in gliomas: a tale of two tumors?

Bryan D. Choi, William T. Curry

ONC201: a new treatment option being tested clinically for recurrent glioblastoma

Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry

When better still might not be good enough

Waldemar Debinski

Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy

Vincent C. O. Njar

Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28

Leonardo Chicaybam, Prasad S. Adusumilli

Exosome mediated phenotypic changes in lung cancer pathophysiology

Yoshihisa Shimada, John D. Minna

Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma

Aaron D. DeWard, Rebecca J. Critchley-Thorne

From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein

Felicia L. Lenzo, William G. Cance

New incriminating evidence against IGF2

Wen Ding, Lina A. Shehadeh

Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect

Paul Grippo, Ajay V. Maker

Branched chain amino acid metabolism and cancer: the importance of keeping things in context

Elizabeth M. Selwan, Aimee L. Edinger

RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver

Satomi Yamamoto, Tomoo Iwakuma

Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy

Michael J. Baine, Chi Lin

Rogue one: another faction of the Wnt empire implicated in assisting GBM progression

Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed

Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway

Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano

Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems

Li Tian, Ashley Chang, Marites P. Melancon

IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm

James P. White

Low-frequency ultrasound may improve drug penetration in colonic mucosa

Qiubing Chen, Bo Xiao, Didier Merlin

Dividing and conquering the variation among variants in EML4-ALK lung cancer

Trever G. Bivona

Unlocking the epigenetic code of T cell exhaustion

Jiazhu Wu, Huidong Shi

KDM1 links nuclear GSK3β to epigenetic alterations

Weijie Guo, Binhua P. Zhou

Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease

Deepa Rangachari, Daniel B. Costa

Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy

Bhagelu R. Achyut, Ali S. Arbab

Neuroendocrine differentiation in prostate cancer: key epigenetic players

Karishma Gupta, Sanjay Gupta

PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression

Kim A. Brogden, Shireen Vali, Taher Abbasi

Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy

Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias

The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies

Keith T. Schmidt, William D. Figg

Information-dense analysis for information-dense understanding

Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen

The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use

Angel Qin, Nithya Ramnath

Immune infiltration, glioma stratification, and therapeutic implications

Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher

Balancing redox stress: anchorage-independent growth requires reductive carboxylation

Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione

Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy

Fabiana Perna, Michel Sadelain

Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells

Alex J. Gooding, William P. Schiemann

Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?

Nathan A. Berger

Microtubule targeting agents in glioma

Anda-Alexandra Calinescu, Maria G. Castro

Moving molecular subtypes to the clinic in gastric cancer

Joseph Chao, Jeeyun Lee, Samuel J. Klempner

Intraoperative subtyping of lung adenocarcinoma: an unmet need

Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli

Emerging roles of FGF signaling in hepatocellular carcinoma

Nana Zheng, Wenyi Wei, Zhiwei Wang

Tregs, Helios and tumor immunity: the sun has not yet risen

Angela M. Thornton, Ethan M. Shevach

Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1

Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof

Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components

Brandon J. Manley, James J. Hsieh

Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer

Salma Kaochar, Nicholas Mitsiades

Letter to the Editor

Epigenetic regulation of PD-L1 expression and pancreatic cancer response to checkpoint immunotherapy

Chunwan Lu, Kebin Liu

Synthetic lethality vs. synthetic viability due to PARP1 and BRCA2 loss

Xia Ding, Shyam K. Sharan

Correspondence

Targeted attack: mechanisms by which ovarian cancers suppress the immune system

Irina V. Tiper, Tonya J. Webb

Brief Report

The impact of neighborhood disadvantage on health-related quality of life among African American and white cancer survivors

Chien-Ching Li, Alicia K. Matthews, Anjali Asthana, Raj C. Shah

Research Highlight

Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base

Scott J. Bultman

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike

Jeffrey J. Tosoian, Emmanuel S. Antonarakis

A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer

Sawsan Rashdan, David E. Gerber

MOAP-1, UBR5 and cisplatin resistance in ovarian cancer

Scott T. Eblen, Amber Bradley

Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer

Weimin Gao

The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)

Theresa L. Whiteside

[¹⁸F]-choline PET/CT as an imaging biomarker for primary liver cancers

Zhenghong Lee

Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best

Yoshio Yamaoka, David Y. Graham

JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function

Theodoros Karantanos, Vassiliki A. Boussiotis

Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer

Angel Qin, Gregory P. Kalemkerian

Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered

Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham

Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells

Praveen Kumar Vemula, Venkatakrishna Rao Jala

Helios—controller of Treg stability and function

Claire Chougnet, David Hildeman

Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation

Jon K. Obst, Marianne D. Sadar

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase

Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird

Fat lure: adipocytes attract cancer cells out of the prostate

Alexandra M. Blee, Haojie Huang

Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers

Guoli Chen, Ming-Tseh Lin

Editorials

Into the eye of the storm: breast cancer’s somatic mutation landscape points to DNA damage and repair

Joanne Ngeow, Emily Nizialek, Charis Eng

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks

Apratim Mitra, Karl Pfeifer, Ki-Sun Park

The STAMPEDE trial: paradigm-changing data through innovative trial design

Bradley C. Carthon, Emmanuel S. Antonarakis

Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway

Derek B. Oien, Jeremy Chien, Nikki Cheng

Feed your gut with caution!

Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar

Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma

Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma

Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients

Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy

Reinhard W. Schulte, Andrew J. Wroe

Externally modulated theranostic nanoparticles

Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi

Intestinal stem cell injury and protection during cancer therapy

Jian Yu

Cancer stem cells in glioma: challenges and opportunities

Jialiang Wang, Yufang Ma, Michael K. Cooper

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury

Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis

Chang-Lung Lee, Jordan M. Blum, David G. Kirsch

DNA ligases as therapeutic targets

Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest

DNA damage tolerance: a double-edged sword guarding the genome

Gargi Ghosal, Junjie Chen

DNA double strand break repair via non-homologous end-joining

Anthony J. Davis, David J. Chen

DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation

Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan

MDM2 and MDMX: alone and together in regulation of p53

Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan

Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase

Lijian Shao, Lixian Wu, Daohong Zhou

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment

Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos

Normal tissue protection for improving radiotherapy: where are the Gaps?

Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman

Improving chemoradiotherapy with nanoparticle therapeutics

Michael Joseph Eblan, Andrew Zhuang Wang

Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization

Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn

Molecular mechanisms involved in tumor repopulation after radiotherapy

Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li

Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules

Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy

Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar

Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma

Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

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S100A1 overexpression stimulates cell proliferation and is predictive of poor outcome in ovarian cancer

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Original Article

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Contemporary surgical management of testicular seminoma

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Review Article

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Published online: 16 July 2024

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Original Article

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Published online: 21 May 2024

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Published online: 16 May 2024

Journal highlight more

Translational Cancer Research is an international, open access, peer-reviewed journal indexed in Scopus and Science Citation Index Expanded (SCIE), focusing on original, science-based researches on clinical, basic and translational aspects. It publishes laboratory studies of novel therapeutic interventions, clinical trials which evaluate new treatment paradigms for cancer, results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients and etc.