(Q29938518)

English

ABL1 BCR::ABL D276G

genetic variant

D276G
ASP276GLY
D295G
RS121913447
BCR-ABL D276G
BCR-ABL ASP276GLY
BCR-ABL D295G
BCR-ABL1 D295G
BCR::ABL D276G

In more languages

default for all languages

No label defined

No description defined

Statements

missense mutation

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

transcript fusion

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

human chromosome 9

genomic assembly

Genome assembly GRCh37

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

133747520

genomic assembly

Genome assembly GRCh37

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

133747520

genomic assembly

Genome assembly GRCh37

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

biological variant of

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

positive therapeutic predictor for

medical condition treated

chronic myeloid leukemia

determination method

CIViC evidence level D

CIViC 2-star trust rating

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/2666

Activity of bosutinib, dasatinib, and nilotinib against 18 imatinib-resistant BCR/ABL mutants

negative therapeutic predictor for

determination method

CIViC evidence level D

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/2663

Activity of bosutinib, dasatinib, and nilotinib against 18 imatinib-resistant BCR/ABL mutants

determination method

CIViC evidence level C

CIViC 1-star trust rating

medical condition treated

chronic myeloid leukemia

statement disputed by

Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/4357

Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib

dasatinib monohydrate

determination method

CIViC evidence level C

CIViC 3-star trust rating

medical condition treated

chronic myeloid leukemia

statement disputed by

Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/4359

Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations

imatinib mesylate

determination method

CIViC evidence level D

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/6246

Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations

determination method

CIViC evidence level D

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/4360

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Identifiers

CIViC variant ID

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

dbSNP Reference SNP number

1 reference

HGVS nomenclature

ENST00000318560.5:c.827A>G

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

NP_005148.2:p.Asp276Gly

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

NM_005157.5:c.827A>G

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

NC_000009.11:g.133747520A>G

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1027

Sitelinks

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