RDS-127: Difference between revisions

| verifiedrevid = 424727703

| image = RDS-127_structure.png

| routes_of_administration =

| excretion =

| molecular_weight = 277.402 g/mol

'''RDS-127''' is a [[drug]] which is used in [[scientific research]]. It acts as a [[D2-like receptor|D₂-like receptor]] [[dopamine agonist|agonist]]<ref name="pmid6401334">{{cite journal | author = Arnerić SP, Long JP, Williams M, ''et al.'' | title = RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 224 | issue = 1 | pages = 161–70 | year = 1983 | month = January | pmid = 6401334 | doi = | url = http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=6401334}}</ref> and also has some [[serotonin agonist|serotonin]] and [[adrenergic agonist]] effects,<ref name="pmid7114973">{{cite journal |author=Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF |title=Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives |journal=Archives Internationales De Pharmacodynamie et De Thérapie |volume=257 |issue=2 |pages=263–73 |year=1982 |month=June |pmid=7114973 |doi= |url=}}</ref><ref name="pmid6145768">{{cite journal |author=Arnerić SP, Long JP |title=Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions |journal=The Journal of Pharmacy and Pharmacology |volume=36 |issue=5 |pages=318–21 |year=1984 |month=May |pmid=6145768 |doi= |url=}}</ref><ref name="pmid3737722">{{cite journal |author=Clark JT, Smith ER |title=Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior |journal=Physiology & Behavior |volume=37 |issue=1 |pages=47–52 |year=1986 |pmid=3737722 |doi= 10.1016/0031-9384(86)90382-3|url=}}</ref><ref name="pmid1685313">{{cite journal |author=Rezaki YE, Ilhan M |title=Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae |journal=Archives Internationales De Pharmacodynamie et De Thérapie |volume=310 |issue= |pages=76–86 |year=1991 |pmid=1685313 |doi= |url=}}</ref> as well as some [[anticholinergic]] action,<ref name="pmid2907277">{{cite journal |author=Sahin I, Ilhan M |title=The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig |journal=Archives Internationales De Pharmacodynamie et De Thérapie |volume=296 |issue= |pages=163–72 |year=1988 |pmid=2907277 |doi= |url=}}</ref><ref name="pmid1692697">{{cite journal |author=Sahin I, Tuncer M, Ilhan M |title=Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice |journal=Archives Internationales De Physiologie et De Biochimie |volume=98 |issue=1 |pages=7–9 |year=1990 |month=March |pmid=1692697 |doi= 10.3109/13813459009115730|url=}}</ref> and produces both [[anorectic]] and [[aphrodisiac|pro-sexual]] effects in animal studies.<ref name="pmid6897285">{{cite journal |author=Arnerić SP, Roetker A, Long JP |title=Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists |journal=Neuropharmacology |volume=21 |issue=9 |pages=885–90 |year=1982 |month=September |pmid=6897285 |doi= 10.1016/0028-3908(82)90080-6|url=}}</ref><ref name="pmid2877677">{{cite journal |author=Kwong LL, Smith ER, Davidson JM, Peroutka SJ |title=Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors |journal=Behavioral Neuroscience |volume=100 |issue=5 |pages=664–8 |year=1986 |month=October |pmid=2877677 |doi= 10.1037/0735-7044.100.5.664|url=}}</ref>

[[Category:Indanes]]