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{{BLP sources|date=February 2013}}
{{Infobox scientist
{{Infobox scientist
| name = Leland H. Hartwell
| name = Leland H. Hartwell
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| prizes = [[Albert Lasker Award]] (1988) [[Nobel Prize in Physiology or Medicine]] (2001)
| prizes = [[Albert Lasker Award]] (1988) [[Nobel Prize in Physiology or Medicine]] (2001)
}}
}}
'''Leland Harrison (Lee) Hartwell''' (born October 30, 1939, in [[Los Angeles, California|Los Angeles]], [[California]]) is former president and director of the [[Fred Hutchinson Cancer Research Center]] in [[Seattle, Washington]]. He shared the 2001 [[Nobel Prize in Physiology or Medicine]] with [[Paul Nurse]] and [[Tim Hunt|R. Timothy Hunt]], for their discoveries of protein molecules that control the division (duplication) of cells.<ref name="illpres">[http://www.nobelprize.org/nobel_prizes/medicine/laureates/2001/illpres/index.html The Nobel Prize in Physiology or Medicine 2001] Illustrated Lecture</ref>
'''Leland Harrison (Lee) Hartwell''' (born October 30, 1939, in [[Los Angeles, California|Los Angeles]], [[California]]) is former president and director of the [[Fred Hutchinson Cancer Research Center]] in [[Seattle, Washington]]. He shared the 2001 [[Nobel Prize in Physiology or Medicine]] with [[Paul Nurse]] and [[Tim Hunt|R. Timothy Hunt]], for their discoveries of protein molecules that control the division (duplication) of cells.<ref name="illpres">http://www.nobelprize.org/nobel_prizes/medicine/laureates/2001/illpres/index.html The Nobel Prize in Physiology or Medicine 2001] Illustrated Lecture</ref>


Working in yeast, Hartwell identified the fundamental role of checkpoints in cell cycle control, and CDC genes such as CDC28, which controls the start of the cycle -- the progression through G1.<ref name="illpres"/>
Working in yeast, Hartwell identified the fundamental role of checkpoints in cell cycle control, and CDC genes such as CDC28, which controls the start of the cycle -- the progression through G1.<ref name="illpres"/>
Line 22: Line 21:
==Education==
==Education==


Hartwell received his bachelor's degree from the [[California Institute of Technology]] in 1961. In 1964, he received his PhD in biology from the [[Massachusetts Institute of Technology]]. From 1965 to 1968, he worked at the [[University of California, Irvine]] as a professor. He moved to the [[University of Washington]] in 1968. In a series of experiments from 1970 to 1971, Hartwell discovered the [[cell division cycle]] (''CDC'') genes in [[baker's yeast]] (''[[Saccharomyces cerevisiae]]''). These genes regulate the cell cycle and [[mutation]]s in the genes are involved in some types of [[cancer]].
Hartwell received his bachelor's degree from the [[California Institute of Technology]] in 1961. In 1964, he received his PhD in biology from the [[Massachusetts Institute of Technology]]. From 1965 to 1968, he worked at the [[University of California, Irvine]] as a professor. He moved to the [[University of Washington]] in 1968. In a series of experiments from 1970 to 1971, Hartwell discovered the [[cell division cycle]] (''CDC'') genes in [[baker's yeast]] (''[[Saccharomyces cerevisiae]]''). These genes regulate the cell cycle and [[mutation]]s in the genes are involved in some types of [[cancer]].
⚫
''Les Prix Nobel. The Nobel Prizes 2001 Tore Frängsmyr. Nobel Foundation: Stockholm
⚫
http://nobelprize.org/medicine/laureates/2001/hartwell-autobio.html Lee Hartwell's Nobel Prize autobiography
⚫
http://myprofile.cos.com/hartwell46 Lee Hartwell's profile, Community of Science


==Awards and honors==
==Awards and honors==


In addition to the [[Nobel Prize]], Hartwell has received many awards and honors including the [[Louisa Gross Horwitz Prize]] from [[Columbia University]] in 1995. He became a member of the [[United States National Academy of Sciences|National Academy of Sciences]] in 1987. In 1996, Hartwell joined the faculty of [[Fred Hutchinson Cancer Research Center]] and in 1997 became its president and director.
In addition to the [[Nobel Prize]], Hartwell has received many awards and honors including the [[Louisa Gross Horwitz Prize]] from [[Columbia University]] in 1995. He became a member of the [[United States National Academy of Sciences|National Academy of Sciences]] in 1987. In 1996, Hartwell joined the faculty of [[Fred Hutchinson Cancer Research Center]] and in 1997 became its president and director.


In 1998 he received the [[Albert Lasker Award for Basic Medical Research]], and the [[Massry Prize]] from the [[Keck School of Medicine]], [[University of Southern California]] in 2000. On July 9, 2003, [[Washington (U.S. state)|Washington]] Governor [[Gary Locke]] awarded the Medal of Merit, the state’s highest honor, to Hartwell. He is also a recipient of the [[Komen Brinker Award for Scientific Distinction]].
In 1998 he received the [[Albert Lasker Award for Basic Medical Research]], and the [[Massry Prize]] from the [[Keck School of Medicine]], [[University of Southern California]] in 2000. On July 9, 2003, [[Washington (U.S. state)|Washington]] Governor [[Gary Locke]] awarded the Medal of Merit, the state’s highest honor, to Hartwell. He is also a recipient of the [[Komen Brinker Award for Scientific Distinction]].

==Research==
His earliest publications focused on temperature sensitive mutations in basic biological processes like DNA, RNA and protein synthesis<ref>{{cite journal | journal= Bacteriology | date=1967 | title=Macromolecule synthesis in temperature-sensitive mutants of yeast | author=Hartwell LH | volume=93 |issue=5 |pages=1662-70 | PMID= 5337848 }}</ref> Subsequent work on cell cycle resulted in an issued US patent. <ref>{{ cite patent | country = US | number = 5674996 | title = Cell cycle checkpoint genes | gdate = 7 October 1997 | inventor = Groudine, Mark T.; Hartwell, Leland H.; Plon, Sharon E.; Weinert, Ted A. }}</ref>


==Other positions==
==Other positions==


Hartwell is the Chairman of the Scientific Advisory Board at the [[Canary Foundation]], a non-profit organization dedicated to developing new technologies for the early detection of [[cancer]]. He is also a founding co-chair of the [[Pacific Health Summit]], and a member of its Executive Committee.<ref>[http://www.pacifichealthsummit.org/about/About_the_Pacific_Health_Summit.pdf Pacific Health Summit, About the Summit, 2011]</ref> In September 2009, it was announced that Hartwell will join the faculty of [[Arizona State University]] as the Virginia G. Piper Chair of Personalized Medicine and co-director of the [[Biodesign Institute]]'s new Center for Sustainable Health with Dr. Michael Birt.<ref>[http://asunews.asu.edu/20090908_hartwell Hartwell to join ASU faculty] ASU News</ref><ref>[http://biodesign.asu.edu/news/arizona-state-university-and-virginia-g-piper-charitable-trust-tap-nobel-prize-winner-dr-lee-hartwell-to-lead-major-health-initiative Arizona State University and Virginia G. Piper Charitable Trust tap Nobel Prize winner Dr. Lee Hartwell to lead major health initiative] Biodesign Institute News</ref>
Hartwell is the Chairman of the Scientific Advisory Board at the [[Canary Foundation]], a non-profit organization dedicated to developing new technologies for the early detection of [[cancer]]. He is also a founding co-chair of the [[Pacific Health Summit]], and a member of its Executive Committee.<ref>[http://www.pacifichealthsummit.org/about/About_the_Pacific_Health_Summit.pdf Pacific Health Summit, About the Summit, 2011]</ref> In September 2009, it was announced that Hartwell will join the faculty of [[Arizona State University]] as the Virginia G. Piper Chair of Personalized Medicine and co-director of the [[Biodesign Institute]]'s new Center for Sustainable Health with Dr. Michael Birt.<ref>[http://asunews.asu.edu/20090908_hartwell Hartwell to join ASU faculty] ASU News</ref><ref>[http://biodesign.asu.edu/news/arizona-state-university-and-virginia-g-piper-charitable-trust-tap-nobel-prize-winner-dr-lee-hartwell-to-lead-major-health-initiative Arizona State University and Virginia G. Piper Charitable Trust tap Nobel Prize winner Dr. Lee Hartwell to lead major health initiative] Biodesign Institute News</ref>

== Lee Hartwell Award ==
This award is given to scientists whose research in yeast has made the most impact in the broader areas of biology.<ref>{{cite web| title= | url=http://www.yeast-meet.org/2010/pages/program.shtml | title=Lee Hartwell Award }}</ref>
* 2012 – [[Stanley Fields (biologist) | Stan Fields]], University of Washington, Seattle
* 2010 – [[Randy Schekman]], University of California, Berkeley
* 2008 – [[Mitsuhiro Yanagida]], Kyoto University
* 2006 – [[Kim Nasmyth]], Oxford University
* 2004 – [[Susan Lindquist]], Whitehead Institute
* 2002 – Leland Hartwell, Fred Hutchinson Cancer Research Center


==References==
==References==
<references/>
<references/>
*{{cite journal |author=Hartwell LH, Culotti J, Reid B |title=Genetic control of the cell-division cycle in yeast. I. Detection of mutants |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=66 |issue=2 |pages=352–9 |year=1970 |month=June |pmid=5271168 |pmc=283051 |url=http://www.pnas.org/cgi/content/abstract/66/2/352}}
⚫
*''Les Prix Nobel''. 2002. The Nobel Prizes 2001, Editor Tore Frängsmyr. Nobel Foundation: Stockholm.
http://news.amrita.edu/news/2011/10/06/nobel-prize-winner-is-adjunct-faculty-at-amrita/

==External links==
⚫
*[http://nobelprize.org/medicine/laureates/2001/hartwell-autobio.html Lee Hartwell's Nobel Prize autobiography]
⚫
*[http://myprofile.cos.com/hartwell46 Lee Hartwell's profile], [[Community of Science]]
*{{ cite patent
| country = US
| number = 5674996
| title = Cell cycle checkpoint genes
| gdate = 7 October 1997
| inventor = Groudine, Mark T.; Hartwell, Leland H.; Plon, Sharon E.; Weinert, Ted A.
}}
*[http://www.cumc.columbia.edu/horwitz/ The Official Site of Louisa Gross Horwitz Prize]


{{Authority control |VIAF=85330694|LCCN=n/97/802342 }}
{{Authority control |VIAF=85330694|LCCN=n/97/802342 }}

Revision as of 17:34, 6 September 2013

Leland H. Hartwell
Born (1939-10-30) October 30, 1939 (age 84)
Los Angeles, California, U.S.
Alma materCalifornia Institute of Technology, Massachusetts Institute of Technology
Known forCell cycle regulation
AwardsAlbert Lasker Award (1988) Nobel Prize in Physiology or Medicine (2001)
Scientific career
FieldsBiology
InstitutionsFred Hutchinson Cancer Research Center
Arizona State University
Biodesign Institute Amrita Vishwa Vidyapeetham

Leland Harrison (Lee) Hartwell (born October 30, 1939, in Los Angeles, California) is former president and director of the Fred Hutchinson Cancer Research Center in Seattle, Washington. He shared the 2001 Nobel Prize in Physiology or Medicine with Paul Nurse and R. Timothy Hunt, for their discoveries of protein molecules that control the division (duplication) of cells.[1]

Working in yeast, Hartwell identified the fundamental role of checkpoints in cell cycle control, and CDC genes such as CDC28, which controls the start of the cycle -- the progression through G1.[1]

Education

Hartwell received his bachelor's degree from the California Institute of Technology in 1961. In 1964, he received his PhD in biology from the Massachusetts Institute of Technology. From 1965 to 1968, he worked at the University of California, Irvine as a professor. He moved to the University of Washington in 1968. In a series of experiments from 1970 to 1971, Hartwell discovered the cell division cycle (CDC) genes in baker's yeast (Saccharomyces cerevisiae). These genes regulate the cell cycle and mutations in the genes are involved in some types of cancer.[2] [3] [4] [5]

Awards and honors

In addition to the Nobel Prize, Hartwell has received many awards and honors including the Louisa Gross Horwitz Prize from Columbia University in 1995.[6] He became a member of the National Academy of Sciences in 1987. In 1996, Hartwell joined the faculty of Fred Hutchinson Cancer Research Center and in 1997 became its president and director.

In 1998 he received the Albert Lasker Award for Basic Medical Research, and the Massry Prize from the Keck School of Medicine, University of Southern California in 2000. On July 9, 2003, Washington Governor Gary Locke awarded the Medal of Merit, the state’s highest honor, to Hartwell. He is also a recipient of the Komen Brinker Award for Scientific Distinction.

Research

His earliest publications focused on temperature sensitive mutations in basic biological processes like DNA, RNA and protein synthesis[7] Subsequent work on cell cycle resulted in an issued US patent. [8]

Other positions

Hartwell is the Chairman of the Scientific Advisory Board at the Canary Foundation, a non-profit organization dedicated to developing new technologies for the early detection of cancer. He is also a founding co-chair of the Pacific Health Summit, and a member of its Executive Committee.[9] In September 2009, it was announced that Hartwell will join the faculty of Arizona State University as the Virginia G. Piper Chair of Personalized Medicine and co-director of the Biodesign Institute's new Center for Sustainable Health with Dr. Michael Birt.[10][11] He is also adjunct faculty at Amrita University in India.[12]

Lee Hartwell Award

This award is given to scientists whose research in yeast has made the most impact in the broader areas of biology.[13]

References

  1. ^ a b "The Nobel Prize in Physiology or Medicine 2001] Illustrated Lecture".
  2. ^ Hartwell LH, Culotti J, Reid B (1970). "Genetic control of the cell-division cycle in yeast. I. Detection of mutants". Proc. Natl. Acad. Sci. U.S.A. 66 (2): 352–9. PMC 283051. PMID 5271168. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ Tore Frängsmyr., ed. (2002). Les Prix Nobel. The Nobel Prizes 2001. Nobel Foundation: Stockholm.
  4. ^ "Lee Hartwell's Nobel Prize autobiography".
  5. ^ "Lee Hartwell's profile, Community of Science".
  6. ^ "The Official Site of Louisa Gross Horwitz Prize".
  7. ^ Hartwell LH (1967). "Macromolecule synthesis in temperature-sensitive mutants of yeast". Bacteriology. 93 (5): 1662–70. PMID 5337848.
  8. ^ US 5674996, Groudine, Mark T.; Hartwell, Leland H.; Plon, Sharon E.; Weinert, Ted A., "Cell cycle checkpoint genes", issued 7 October 1997 
  9. ^ Pacific Health Summit, About the Summit, 2011
  10. ^ Hartwell to join ASU faculty ASU News
  11. ^ Arizona State University and Virginia G. Piper Charitable Trust tap Nobel Prize winner Dr. Lee Hartwell to lead major health initiative Biodesign Institute News
  12. ^ "Amrita News: Nobel-prize winner is adjunct faculty at Amrita". October 6, 2011.
  13. ^ "Lee Hartwell Award".

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