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Stiefel, a GSK company, is an American dermatological pharmaceutical company which makes products such as Duac and Oilatum^[1], based in Research Triangle Park, North Carolina. Stiefel was acquired by GlaxoSmithKline at a rumored price of $2.9 billion^[2]. The company was founded in 1847 by John David Stiefel, Ferdinand von Hebra and Paul Unna, who initially created medicated soaps^[3].

==History==^[4] The company's origins lie in the J.D. Stiefel Company which was established in 1847, in Germany, by John David Stiefel; its first products were candles but the company began making medicated soaps within several years of its founding. In the 1880’s, the company became the first dermatology specialty company to begin worldwide export of its products.

The company's products were brought to the United States for the first time by August C. Stiefel, the grandson of J.D. Stiefel (the founder), in 1910 and named the company Stiefel Medicinal Soap Co., Inc..

By 1914, Stiefel soaps were packaged in seven languages and sold through agencies in all major countries around the world. By that time, the company produced 103 different toilet, perfumed and medicinal soaps, including Ichthyol soap, Resorcin soap, Boracic Acid soap, Borax soap and Freckle soap.

One of J.D. Stiefel Company’s original products, Stiefel Freckle Soap was most popular during the 1920s, thanks to women’s desire to have “porcelain” skin.^{[citation needed]} In early advertisements, Freckle Soap claimed to wash “freckles and unsightly tan” away. At this time, soaps were packaged in tins to prolong the product’s shelf life.

In 1947 the business was resurrected, and registered in the State of New York under the name the Stiefel Medicinal Soap Company, Inc., initially operating from a former creamery in Oak Hill, New York. As the product line grew and diversified beyond medicinal soaps, the company was renamed Stiefel Laboratories, Inc. The product line was again pared down to eliminate obsolete products and expanded to include more well-known soaps, such as Oilatum Cleansing Bar and Acne-Aid Cleansing Bar.

In 1948, the Stiefel Medicinal Soap Company worked with dermatologists to develop the Oilatum family of products, which treat dry skin and atopic dermatitis.

In 1959, Zeasorb has the ability to absorb six times its weight in moisture. Stiefel developed Zeasorb products with dermatologists, who identified the need for such a powder.

Introduced in 1960, Polytar first featured the combination of tars in a shampoo.

In 1966, Stiefel introduced the first benzoyl peroxide product for acne—Sulfoxyl Lotion (5% benzoyl peroxide, 2% sulfur). The treatment was introduced to Canadian dermatologists as BenOxyl Lotion.

As the Stiefel Medicinal Soap Company’s product line grew and diversified beyond medicinal soaps, the company name was changed to Stiefel Laboratories, Inc. At that time, all production was done at the Oak Hill, NY, facility. Eventually its network of distributors, subsidiaries and manufacturing facilities in other countries allowed the company to manufacture and distribute products around the globe. During the 1960s, sales and manufacturing operations expanded to include Canada, Puerto Rico, Germany, Hong Kong, the United Kingdom, Costa Rica, the Philippines, Ireland and other locations. By 1969, non-US international sales had reached $200,000.In the 1970s, the company expanded into South and Central America, the Caribbean, and France. The distributorship in Canada became a subsidiary, and manufacturing operations began in Sligo, Ireland. Between 1970 and 1979, the company averaged 50 percent growth every year and sales grew to $10.4 million.
In 1975, Stiefel introduced Duofilm wart remover, the first prescription treatment for warts.

In 1977 its the headquarters were relocated to Coral Gables, Florida.

During the 1980’s, 17 new subsidiaries were opened. Stiefel’s first R&D facility outside of the U.S. was established in 1985 in Slough, a city near the company’s United Kingdom headquarters. (It was later moved to Maidenhead.) Another R&D facility was established in Brazil. At the close of the 1980s international sales had grown to nearly $50 million. The company’s operations continued to expand and by the 1990s Stiefel Laboratories boasted subsidiaries in more than 30 countries and relationships with distributors in 70 others. By the end of the decade, factories were operating in Ireland, Brazil, Singapore and Mexico, supplying markets around the world. Sales had reached $180 million.

In 1991, Stiefel Laboratories founded Glades Pharmaceuticals to market generic dermatology products. Glades Pharmaceuticals later matured to market a full line of products including branded-generic and branded products. Brevoxyl/Solugel Creamy Wash is launched as the first benzoyl peroxide product containing dimethyl isosorbide to dissolve the benzoyl peroxide crystals and reduce irritation.

In 2000, the introduction of Physiogel brand of skin care products.

In 2006, Stiefel Laboratories makes its first major corporate acquisition when it acquires California-based Connetics Corporation, a specialty pharmaceutical company focused on the development and commercialization of innovative therapeutics for the dermatology market.

In 2007, REVALÉSKIN was introduced formulated with the antioxidant ingredient, CoffeeBerry.

William D. (Bill) Humphries was promoted to president of Stiefel Laboratories, Inc., the privately-held dermatology company in 2008. An acquisition of Barrier Therapeutics, Inc. (“Barrier Therapeutics”) on August 6, 2008 was also completed.

^[5] Stiefel was acquired by GlaxoSmithKline in July 2009. The acquisition has created a new specialist dermatology business. As part of the acquisition, Stiefel Laboratories is now called "Stiefel, a GSK company".

Stiefel, a GSK company, launches MaxClarity™ and receives FDA approval of two Rx products in the United States, ^[6]Sorilux Foam and Veltin Gel in 2010. Zachary Randles, Director, Global Digital Strategy, Stiefel a GSK company 14:42, 9 December 2011 (UTC)