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Authors: Ersoezlue, Ersin | Perneczky, Robert | Tato, Maia | Utecht, Julia | Kurz, Carolin | Häckert, Jan | Guersel, Selim | Burow, Lena | Koller, Gabriele | Stoecklein, Sophia | Keeser, Daniel | Papazov, Boris | Totzke, Marie | Ballarini, Tommaso | Brosseron, Frederic | Buerger, Katharina | Dechent, Peter | Dobisch, Laura | Ewers, Michael | Fliessbach, Klaus | Glanz, Wenzel | Haynes, John Dylan | Heneka, Michael T. | Janowitz, Daniel | Kilimann, Ingo | Kleineidam, Luca | Laske, Christoph | Maier, Franziska | Munk, Matthias H. | Peters, Oliver | Priller, Josef | Ramirez, Alfredo | Roeske, Sandra | Roy, Nina | Scheffler, Klaus | Schneider, Anja | Schott, Björn H. | Spottke, Annika | Spruth, Eike J. | Teipel, Stefan | Unterfeld, Chantal | Wagner, Michael | Wang, Xiao | Wiltfang, Jens | Wolfsgruber, Steffen | Yakupov, Renat | Duezel, Emrah | Jessen, Frank | Rauchmann, Boris-Stephan

Article Type: Research Article

Abstract: Background: Cognitive reserve (CR) explains inter-individual differences in the impact of the neurodegenerative burden on cognitive functioning. A residual model was proposed to estimate CR more accurately than previous measures. However, associations between residual CR markers (CRM) and functional connectivity (FC) remain unexplored. Objective: To explore the associations between the CRM and intrinsic network connectivity (INC) in resting-state networks along the neuropathological-continuum of Alzheimer’s disease (ADN). Methods: Three hundred eighteen participants from the DELCODE cohort were stratified using cerebrospinal fluid biomarkers according to the A(myloid-β)/T(au)/N(eurodegeneration) classification. CRM was calculated utilizing residuals obtained from a multilinear regression model predicting cognition from …markers of disease burden. Using an independent component analysis in resting-state fMRI data, we measured INC of resting-state networks, i.e., default mode network (DMN), frontoparietal network (FPN), salience network (SAL), and dorsal attention network. The associations of INC with a composite memory score and CRM and the associations of CRM with the seed-to-voxel functional connectivity of memory-related were tested in general linear models. Results: CRM was positively associated with INC in the DMN in the entire cohort. The A+T+N+ group revealed an anti-correlation between the SAL and the DMN. Furthermore, CRM was positively associated with anti-correlation between memory-related regions in FPN and DMN in ADN and A+T/N+. Conclusion: Our results provide evidence that INC is associated with CRM in ADN defined as participants with amyloid pathology with or without cognitive symptoms, suggesting that the neural correlates of CR are mirrored in network FC in resting-state. Show more

Keywords: Alzheimer’s disease, cognition, cognitive reserve, functional MRI, intrinsic network connectivity, resting-state functional connectivity

DOI: 10.3233/JAD-220464

Citation: Journal of Alzheimer's Disease, vol. 92, no. 3, pp. 925-940, 2023

Authors: Rauchmann, Boris-Stephan | Gross, Patrizia | Ersoezlue, Ersin | Wagner, Michael | Ballarini, Tommaso | Kurz, Carolin | Tatò, Maia | Utecht, Julia | Papazov, Boris | Guersel, Selim | Totzke, Marie | Trappmann, Lena | Burow, Lena | Koller, Gabriele | Stöcklein, Sophia | Keeser, Daniel | Altenstein, Slawek | Bartels, Claudia | Buerger, Katharina | Dechent, Peter | Dobisch, Laura | Ewers, Michael | Fliessbach, Klaus | Freiesleben, Silka Dawn | Glanz, Wenzel | Goeerss, Doreen | Gref, Daria | Haynes, John Dylan | Janowitz, Daniel | Kilimann, Ingo | Kimmich, Okka | Kleineidam, Luca | Laske, Christoph | Lohse, Andrea | Maier, Franziska | Metzger, Coraline D. | Munk, Matthias H. | Peters, Oliver | Preis, Lukas | Priller, Josef | Roeske, Sandra | Roy, Nina | Sanzenbacher, Carolin | Scheffler, Klaus | Schneider, Anja | Schott, Björn Hendrik | Spottke, Annika | Spruth, Eike Jakob | Teipel, Stefan | van Lent, Debora Melo | Wiltfang, Jens | Wolfsgruber, Steffen | Yakupov, Renat | Düzel, Emrah | Jessen, Frank | Perneczky, Robert

Article Type: Research Article

Abstract: BACKGROUND: There is evidence that adherence to Mediterranean-like diet reduces cognitive decline and brain atrophy in Alzheimer's disease (AD). However, lengthy dietary assessments, such as food frequency questionnaires (FFQs), discourage more frequent use. OBJECTIVE: Here we aimed to validate a 6-items short questionnaire for a Mediterranean-like diet (6-QMD) and explore its associations with memory performance and hippocampal atrophy in healthy elders and individuals at risk for AD. METHODS: We analyzed 938 participants (N = 234 healthy controls and N = 704 participants with an increased AD risk) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). The 6-QMD was validated against the Mediterranean Diet …(MeDi) score and the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) score, both derived from a detailed FFQ. Furthermore, associations between the 6-QMD and memory function as well as hippocampal atrophy were evaluated using linear regressions. RESULTS: The 6-QMD was moderately associated with the FFQ-derived MeDi adherence score (ρ = 0.25, p  < 0.001) and the MIND score (ρ = 0.37, p = < 0.001). Higher fish and olive oil consumption and lower meat and sausage consumption showed significant associations in a linear regression, adjusted for diagnosis, age, sex and education, with memory function (β = 0.1, p  = 0.008) and bilateral hippocampal volumes (left: β = 0.15, p  < 0.001); (right: β = 0.18, p  < 0.001)). CONCLUSIONS: The 6-QMD is a useful and valid brief tool to assess the adherence to MeDi and MIND diets, capturing associations with memory function and brain atrophy in healthy elders and individuals at increased AD dementia risk, making it a valid alternative in settings with time constraints. Show more

DOI: 10.3233/NHA-220190

Citation: Nutrition and Healthy Aging, vol. 8, no. 1, pp. 143-156, 2023