Your search for: 'author:("Sellal, François")' has returned 11 results. (0.022s) Save search

Authors: Gilson, Virginie | Mbebi-Liegeois, Corinne | Sellal, François | de Barry, Jean

Article Type: Research Article

Abstract: Numerous studies have shown that amyloid-β (Aβ) modulate intracellular metabolic cascades and an intracellular Ca2+ homeostasis and a cell surface NMDA receptor expression alteration in Alzheimer’s disease (AD). However most of these findings have been obtained by using non-physiological Aβ concentrations. The present study deals with the effect of low Aβ concentrations on cellular homeostasis. We used nerve growth factor-differentiated PC12 cells and murine cortical neurons sequentially treated with low chronic monomeric or small oligomeric Aβ concentrations and high acute oligomeric Aβ concentrations to bring out a priming effect of chronic treatment on subsequently high Aβ concentrations-elicited cellular response. Both …cell types indeed displayed an enhanced capacity to bind oligomeric Aβ after monomeric or small oligomeric Aβ application. Furthermore, the results show that monomeric Aβ1–42 application to the cells induces an increase of the Ca2+ -response and of the membrane expression of the extrasynaptic subunit of the NMDA receptor GluN2B in PC12 cells, while the opposite effects were observed in cultured neurons. This suggests a sequential interaction of Aβ with the cellular plasma membrane involving monomers or small Aβ oligomers which would facilitate the binding of the deleterious high molecular Aβ oligomers. This mechanism would explain the slow progression of AD in the human nervous system and the deep gradient of neuronal death observed around the amyloid plaques in the nervous tissue. Show more

Keywords: Alzheimer’s disease, amyloid-β, cortical neurons, homeostasis, in vitro model, intracellular calcium, NMDA receptor, oligomers, pathogenesis, PC12 cells

DOI: 10.3233/JAD-142529

Citation: Journal of Alzheimer's Disease, vol. 47, no. 2, pp. 453-466, 2015

Authors: Cretin, Benjamin | Sellal, François | Philippi, Nathalie | Bousiges, Olivier | Di Bitonto, Laure | Martin-Hunyadi, Catherine | Blanc, Frederic

Article Type: Research Article

Abstract: Background: Aside from rare case reports, only one study, with 12 patients, has addressed the phenotypic presentation of epilepsy in clinically defined amnestic mild cognitive impairment (aMCI, presumed to correspond to the AD prodromal stage): the authors highlighted a pharmacosensitive non-convulsive partial epileptic syndrome most probably related to the temporal or temporo-frontal cortices. Objective: The objective of this study was to verify the existence and the syndromic features of epileptic prodromal AD in a tertiary Memory Clinic. Methods: We conducted a retrospective, single-center study of the electro-radio-clinical features of 13 cases of epileptic prodromal AD patients (3.1% of a cohort …of MCI, n  = 430 subjects), selected on both clinical criteria and CSF biomarkers. Results: In our patients, a pharmacosensitive temporal lobe epilepsy syndrome, inaugurating prodromal AD, started at a mean age of 63 years (±12.8 years) and preceded MCI diagnosis by 4 to 7 years. At the stage of aMCI, median MMSE score was 26 and imaging showed mild hippocampal atrophy. After almost one year under treatment, cognitive complaints were not relieved but the MMSE score remained stable at 26 for 11 patients (2 patients were excluded from analysis because of the onset of aphasic or neurovisual symptoms altering MMSE scoring). Conclusion: Our data, in conjunction with those of the 12 previously described subjects, suggest the existence of a currently unrecognized inaugural epilepsy syndrome of sporadic AD. Such a syndrome could be called the epileptic variant of AD because seizures are its sole feature for more than 2.5 years. Show more

Keywords: Alzheimer’s disease, mild cognitive impairment, partial seizures, temporal lobe epilepsy

DOI: 10.3233/JAD-150096

Citation: Journal of Alzheimer's Disease, vol. 52, no. 3, pp. 1125-1133, 2016

Authors: Hautecloque-Raysz, Geoffroy | Sellal, François | Bousiges, Olivier | Phillipi, Nathalie | Blanc, Frédéric | Cretin, Benjamin

Article Type: Research Article

Abstract: Background: The medium term outcome (over more than one year) of epileptic prodromal AD (epAD) patients treated with antiseizure medications (ASMs) is unknown in terms of seizure response, treatment tolerability, and cognitive and functional progression. Objective: To describe such medium term outcome over a mean of 5.1±2.1 years. Methods: We retrospectively compared 19 epAD patients with 16 non-epileptic prodromal AD (nepAD) patients: 1) at baseline for demographics, medical history, cognitive fluctuations (CFs), psychotropic medications, MMSE scores, visually rated hippocampal atrophy, CSF neurodegenerative biomarkers, and standard EEG recordings; 2) during follow-up (FU) for psychotropic medications, MMSE progression, and conversion to dementia. …In the epAD group, we analyzed baseline and FU types of seizures as well as each line of ASM with the corresponding efficacy and tolerability. Results: At baseline, the epAD group had more CFs than the nepAD group (58% versus 20%, p  = 0.03); focal impaired awareness seizures were the most common type (n  = 12, 63.1%), occurring at a monthly to quarterly frequency (89.5%), and were well controlled with monotherapy in 89.5% of cases (including 63.1% seizure-free individuals). During FU, treated epAD patients did not differ significantly from nepAD patients in MMSE progression or in conversion to dementia. Conclusion: Epilepsy is commonly controlled with ASMs over the medium term in epAD patients, with similar functional and cognitive outcomes to nepAD patients. Pathophysiologically, epilepsy is likely to be an ASM-modifiable cognitive aggravating factor at this stage of AD. Show more

Keywords: Alzheimer’s disease, antiseizure medications, cerebrospinal fluid, late-onset epilepsy, mild cognitive impairment

DOI: 10.3233/JAD-221197

Citation: Journal of Alzheimer's Disease, vol. 94, no. 3, pp. 1057-1074, 2023

Authors: Krolak-Salmon, Pierre | Dubois, Bruno | Sellal, François | Delabrousse-Mayoux, Jean-Philippe | Vandel, Pierre | Amieva, Hélène | Jeandel, Claude | Andrieu, Sandrine | Perret-Liaudet, Armand

Article Type: Editorial

Abstract: The French Minister of Health published a decree on May 29th of 2018 removing the drugs used to fight against symptoms due to Alzheimer’s disease (donepezil, rivastigmine, galantamine, memantine) from the list of available reimbursed drugs. This follows the advice delivered by the High Authority for Health in 2016 and 2018 stating an “insufficient medical benefit and dangerousness because of significant side effects”. The main French scientific and medical societies and professional associations want to state here their deep disagreement regarding this unfair decision. The evidence-based medicine related to these drugs reaches a high level in literature, whereas the clinical …relevance of these treatments must be considered with co-prescription of psychosocial interventions and related approaches. As no serious pharmacovigilance signal has been provided by health authorities, the ratio of benefits/risks favors these drugs. Show more

Keywords: Alzheimer’s disease, drug, health policy, reimbursement

DOI: 10.3233/JAD-180843

Citation: Journal of Alzheimer's Disease, vol. 66, no. 2, pp. 425-427, 2018

Authors: El-Hayeck, Rita | Baddoura, Rafic | Wehbé, Amine | Bassil, Nazem | Koussa, Salam | Abou Khaled, Karine | Richa, Sami | Khoury, Rita | Alameddine, Abbas | Sellal, François

Article Type: Research Article

Abstract: Background: The Mini-Mental State Examination (MMSE) has not been validated in the Lebanese population and no normative data exist at the national level. Objective: To evaluate the reliability and validity of an Arabic version of MMSE developed by the “Groupe de Travail sur les Démences de l’Université Saint Joseph” (A-MMSE(GTD-USJ)) and to provide normative data by gender, age, and education in adults over 55. Methods: Study design: national cross-sectional survey. Study population: 1,010 literate community-dwelling Lebanese residents aged 55 and above. Outcomes: reproducibility, internal consistency, sensitivity, specificity, predictive values, and area under the curve of the A-MMSE(GTD-USJ) for the detection …of cognitive impairment using the Clinical Dementia Rating (CDR) as the gold standard. Normative data were established from 720 healthy adults. A-MMSE(GTD-USJ) scores corresponding to the 5th, 10th, 15th, and 50th percentiles were identified according to gender, age, and education. Results: Intra-rater and inter-rater test-retest score correlations were 0.89 and 0.72, respectively. Cronbach alpha coefficient for internal consistency of the A-MMSE(GTD-USJ) was 0.71. A threshold value of 23 provided a sensitivity of 80% and a specificity of 89.4%. The area under the curve was 0.92. A-MMSE(GTD-USJ) scores increased with education and decreased with age. Women had significantly lower scores than men. Normative data for A-MMSE(GTD-USJ) stratified by gender, age, and education were generated. Conclusion: In reference to the CDR, the A-MMSE(GTD-USJ) is a valid tool to assess cognitive status among Lebanese subjects aged 55 and above. Normative data will help clinicians in detecting cognitive impairment in this population. Show more

Keywords: Arabic version, dementia, Lebanon, mini-mental state examination, normative data, reliability, validity

DOI: 10.3233/JAD-181232

Citation: Journal of Alzheimer's Disease, vol. 71, no. 2, pp. 525-540, 2019

Authors: Blanc, Frederic | Philippi, Nathalie | Cretin, Benjamin | Kleitz, Catherine | Berly, Laetitia | Jung, Barbara | Kremer, Stephane | Namer, Izzie Jacques | Sellal, François | Jaulhac, Benoit | de Seze, Jerome

Article Type: Research Article

Abstract: Introduction: Descriptions of Lyme disease and dementia are rare. Objective: To describe patients with dementia and a positive “intrathecal anti-Borrelia antibody index” (AI), specific for neuroborreliosis. Methods: Among 1,594 patients seen for dementia, we prospectively identified and studied 20 patients (1.25%) with dementia and a positive AI. Patients underwent a battery of neuropsychological tests brain, MRI, FDG-PET, and cerebrospinal fluid (CSF) analysis. An etiological diagnosis of the dementia was made at the end of the follow-up of 5.0 ± 2.9 years. Results: We found two groups of patients with dementia, the first (n = 7, 0.44%) with certain neuroborreliosis and …stability or mild improvement of dementia after treatment by antibiotics and the second (n = 13, 0.81%) with progressive worsening of dementia, despite the antibiotics. In the second group, the final diagnoses were Alzheimer’s disease (AD) (n = 4), AD and Lewy body disease (LBD) (n = 3), LBD (n = 1), FTLD (n = 3), hippocampal sclerosis (n = 1), and vascular dementia (n = 1). We did not observe any differences in cognitive test between the two patient groups at baseline. Brain MRI showed more focal atrophy and FDG-PET showed more frontal hypometabolism in the second group. Tau, p-tau, and Aβ42 concentrations in the CSF were normal in the neuroborreliosis group, and coherent with diagnosis in the second. Conclusion: Pure Lyme dementia exists and has a good outcome after antibiotics. It is advisable to do Lyme serology in demented patients, and if serology is positive, to do CSF analysis with AI. Neurodegenerative dementia associated with positive AI also exists, which may have been revealed by the involvement of Borrelia in the CNS. Show more

Keywords: Alzheimer's disease, dementia, frontotemporal lobe dementia, hippocampal sclerosis, intrathecal anti-Borrelia antibody index, Lewy body dementia, Lewy body disease, Lyme disease, Lyme neuroborreliosis, vascular dementia

DOI: 10.3233/JAD-130446

Citation: Journal of Alzheimer's Disease, vol. 41, no. 4, pp. 1087-1093, 2014

Authors: El-Hayeck, Rita | Wehbé, Amine | Baddoura, Rafic | Khoury, Rita | Bassil, Nazem | Abou Khaled, Karine | Koussa, Salam | Richa, Sami | Alameddine, Abbas | Sellal, François

Article Type: Research Article

Abstract: Background: Verbal fluency tasks are frequently used for neuropsychological assessment in clinical practice and research. It consists of two tasks namely category and letter fluency tests. Objective: To determine normative values in category (animals, vegetables, fruits) and letter fluency [Mim ( ) “M”, Alif ( ) “A”, Baa ( ) “B”] tasks in Arabic language in 60 s. Methods: This study was a cross-sectional national survey and included 859 community-dwelling, cognitively intact Lebanese residents aged ≥55 years. Norms were presented according to age (55–64 years, 65–74 years, ≥75 years), sex and level of education (illiterate, no diploma, primary certificate, baccalaureate or …higher). Results: Level of education had the most significant positive effect on verbal fluency tasks performance amongst Lebanese older adults. The negative effect of older age was more prominent in the category fluency task compared to the letter fluency task. Women outperformed men in vegetables and fruits categories. Conclusion: This study provides clinicians with normative scores of category and letter fluency tests, which can be used for neuropsychological assessment of older Lebanese patients being evaluated for cognitive disorders. Show more

Keywords: Cognitive aging, dementia, language tests, Lebanon, neuropsychological tests, reference standards

DOI: 10.3233/JAD-221121

Citation: Journal of Alzheimer's Disease, vol. 93, no. 1, pp. 321-332, 2023

Authors: Benoit, Michel | Berrut, Gilles | Doussaint, Johanna | Bakchine, Serge | Bonin-Guillaume, Sylvie | Frémont, Patrick | Gallarda, Thierry | Krolak-Salmon, Pierre | Marquet, Thierry | Mékiès, Claude | Sellal, François | Schuck, Stéphane | David, Renaud | Robert, Philippe

Article Type: Research Article

Abstract: Apathy and depression are the most frequent neuropsychiatric symptoms in Alzheimer's disease (AD). In a cross-sectional observational study of 734 subjects with probable mild AD, we evaluated the prevalence of apathy and depression. After the use of specific diagnostic criteria, we tested the interaction between the two syndromes and their relation with specific comorbidities, and different functional outcomes. Depression was diagnosed using the diagnostic criteria for depression in AD, and apathy with the diagnostic criteria for apathy in neuropsychiatric disorders. According to the specific diagnostic criteria, depression had a 47.9% prevalence, while apathy prevalence was 41.6%. Apathy and depression were …associated in 32.4% of patients (n = 225). 9.4% (n = 65) had only apathy, 15.4% (n = 107) had only depression, and 42.9% had no apathy and no depression (n = 298). The three most frequent depressive symptoms were fatigue or loss of energy (59.4%), decreased positive affect or pleasure in response to social contacts and activities (46.2%), and psychomotor agitation or retardation (36.9%). Concerning apathy, loss of goal-directed cognition was the most frequently altered (63.6%), followed by loss of goal-directed action (60.6%) and loss of goal-directed emotion (43.8%). Patients with both apathy and depression more frequently required a resource allowance for dependency. Neurological comorbidities were more frequent in the “apathy and depression” and “depression alone” groups (p < 0.001). Apathy and depression overlap considerably, and this might be explained by the presence of some non-specific symptoms in both diagnostic criteria. The need for social support is higher when a patient fulfills the two diagnostic criteria. Show more

Keywords: Alzheimer's disease, apathy, depressive symptoms, dementia

DOI: 10.3233/JAD-2012-112003

Citation: Journal of Alzheimer's Disease, vol. 31, no. 2, pp. 325-334, 2012

Authors: Sellal, François | Wallon, David | Martinez-Almoyna, Laurent | Marelli, Cecilia | Dhar, Abhinav | Oesterlé, Héléne | Rovelet-Lecrux, Anne | Rousseau, Stéphane | Kourkoulis, Christina E. | Rosand, Jon | DiPucchio, Zora Y. | Frosch, Matthew | Gombert, Claudine | Audoin, Bertrand | Miné, Manuèle | Riant, Florence | Frebourg, Thierry | Hannequin, Didier | Campion, Dominique | Greenberg, Steven M. | Tournier-Lasserve, Elisabeth | Nicolas, Gaël

Article Type: Research Article

Abstract: Background: Specific APP mutations cause cerebral amyloid angiopathy (CAA) with or without Alzheimer’s disease (AD). Objective: We aimed at reporting APP mutations associated with CAA, describe the clinical, cerebrospinal fluid AD biomarkers, and neuroimaging features, and compare them with the data from the literature. Methods: We performed a retrospective study in two French genetics laboratories by gathering all clinical and neuroimaging data from patients referred for a genetic diagnosis of CAA with an age of onset before 66 years and fulfilling the other Boston revised criteria. We studied the segregation of mutations in families and performed a comprehensive literature review of all cases …reported with the same APP mutation. Results: We screened APP in 61 unrelated French patients. Three mutations, located in the Aβ coding region, were detected in five patients from three families: p.Ala692Gly (Flemish), p.Glu693Lys (Italian), and p.Asp694Asn (Iowa). Patients exhibited CAA and progressive cognitive impairment associated with cortical calcifications in the Iowa and Italian mutation carriers, but not the patient carrying the Flemish mutation. Conclusions: This is the first evidence of cortical calcification in patients with an APP mutation other than the Iowa mutation. We discuss the radiological, cerebrospinal fluid, and clinical phenotype of patients carrying these mutations in the literature. Show more

Keywords: Alzheimer’s disease, amyloid-β, APP, calcification, cerebral amyloid angiopathy, mutation

DOI: 10.3233/JAD-160709

Citation: Journal of Alzheimer's Disease, vol. 56, no. 1, pp. 37-46, 2017

Authors: Wallon, David | Rousseau, Stéphane | Rovelet-Lecrux, Anne | Quillard-Muraine, Muriel | Guyant-Maréchal, Lucie | Martinaud, Olivier | Pariente, Jérémie | Puel, Michèle | Rollin-Sillaire, Adeline | Pasquier, Florence | Le Ber, Isabelle | Sarazin, Marie | Croisile, Bernard | Boutoleau-Bretonnière, Claire | Thomas-Antérion, Catherine | Paquet, Claire | Moreaud, Olivier | Gabelle, Audrey | Sellal, François | Sauvée, Mathilde | Laquerrière, Annie | Duyckaerts, Charles | Delisle, Marie-Bernadette | Streichenberger, Nathalie | Lannes, Béatrice | Frebourg, Thierry | Hannequin, Didier | Campion, Dominique | The collaborators of the GMAJ project

Article Type: Research Article

Abstract: We describe 56 novel autosomal dominant early-onset Alzheimer disease (ADEOAD) families with PSEN1, PSEN2, and AβPP mutations or duplications, raising the total of families with mutations on known genes to 111 (74 PSEN1, 8 PSEN2, 16 AβPP, and 13 AβPP duplications) in the French series. In 33 additional families (23% of the series), the genetic determinism remained uncharacterized after this screening. Cerebrospinal fluid (CSF) biomarker levels were obtained for patients of 58 families (42 with known mutations and 16 without genetic characterization). CSF biomarkers profile was consistent with an AD diagnosis in 90% of families carrying mutations on known genes. …In families without mutation, CSF biomarkers were consistent with AD diagnosis in 14/16 cases. Overall, these results support further genetic heterogeneity in the determinism of ADEOAD and suggest that other major genes remain to be characterized. Show more

Keywords: Alzheimer's disease, AβPP, CSF biomarkers, early-onset, genetics, PSEN1, PSEN2

DOI: 10.3233/JAD-2012-120172

Citation: Journal of Alzheimer's Disease, vol. 30, no. 4, pp. 847-856, 2012