Your search for: 'author:("Pantoni, Leonardo")' has returned 8 results. (0.015s) Save search

Authors: Salvadori, Emilia | Poggesi, Anna | Pracucci, Giovanni | Inzitari, Domenico | Pantoni, Leonardo | on behalf of the VMCI-Tuscany Study Group

Article Type: Research Article

Abstract: Background and Objective: Vascular cognitive impairment may have a selective neuropsychological profile. We developed a battery for assessing mild cognitive impairment (MCI) in patients with small vessel disease (SVD), its applicability, and psychometric properties. Methods: Among those proposed by the 2006 NINDS-CSN Consensus Conference, we selected tests for which norms based on healthy Italians and equivalent scores methodology were available. Confirmatory factor analysis was applied to ascertain the fit of the theoretically assumed dimensions to empirical data and to derive each cognitive dimension compound measures. Results: The entire battery was applied to 146 out of a cohort of 201 patients …with MCI and SVD. Most tests showed good applicability. Fifty-five patients, who were older and cognitively more impaired, proved unable to complete the Trail Making Test part B, the Rey-Osterrieth Complex Figure, and the Stroop test, and were excluded from the analysis. Among the remaining patients, Mini-Mental State Examination proved largely normal, while Rey-Osterrieth Complex Figure, Symbol digit modalities test, and Trail Making Test part B were most frequently abnormal. Confirmatory factor analysis showed a good fit of the 4-factor theoretical model to empirical data. Praxis domain resulted in the highest percentage of abnormal performance (65%), followed by Memory and Attention/EF domains (19% and 15%), and Language (8%). Conclusions: Our battery proved to be comprehensive, robust, and applicable. Attention-executive dysfunction and impaired memory and visuo-constructional abilities, were the prominent features. The assessment of the Consensus Conference, that included Trial Making Test, looks poorly applicable to older and cognitively impaired patients. Show more

Keywords: Cognitive assessment, confirmatory factor analysis, psychometric properties, small vessel disease, neuropsychology, subcortical ischemic vascular disease

DOI: 10.3233/JAD-141449

Citation: Journal of Alzheimer's Disease, vol. 43, no. 4, pp. 1313-1323, 2015

Authors: Pantoni, Leonardo | Poggesi, Anna | Diciotti, Stefano | Valenti, Raffaella | Orsolini, Stefano | Della Rocca, Eleonora | Inzitari, Domenico | Mascalchi, Mario | Salvadori, Emilia

Article Type: Research Article

Abstract: Background and Objective: Mild cognitive impairment (MCI) patients with small vessel disease (SVD) are at high dementia risk. We tested the effects of cognitive rehabilitation in these patients using the Attention Process Training-II (APT-II) program in a single-blinded, randomized clinical trial. Methods: Patients were randomized to APT-II or standard care and evaluated at baseline, 6, and 12 months with functional, quality of life, cognitive tests, and resting state functional MRI (rsfMRI). Results: Forty-six patients were enrolled and 43 (mean±SD age 75.1±6.8) completed the study. No change was seen in functionality and quality of life between treated and non-treated patients. However, …the Rey Auditory-Verbal Learning Test immediate recall showed a significant improvement in treated compared to non-treated group (change score 6 versus 12 months: 1.8±4.9 and –1.4±3.8, p  = 0.021; baseline versus 12 months: 3.8±6.1 and 0.2±4.4, p  = 0.032). A higher proportion of treated patients had stable/better evaluation compared to non-treated group on Visual search test (6 versus 12 months: 95% versus 71%, p  = 0.038) and Rey–Osterrieth Complex Figure copy (6 versus 12 months: 95% versus 67%, p  = 0.027). RsfMRI, performed in a subsample, showed that the difference between follow-up and baseline in synchronization of activity in cerebellar areas was significantly greater in treated than in non-treated patients. Conclusion: We were unable to show a significant effect in quality of life or functional status in treated patients with MCI and SVD. However, APT-II produces some beneficial effects in focused attention and working memory and seems to increase activity in brain circuits involved in cognitive processes. Show more

Keywords: Cerebrovascular disorders, clinical trial, cognitive dysfunction, functional magnetic resonance imaging, rehabilitation

DOI: 10.3233/JAD-170428

Citation: Journal of Alzheimer's Disease, vol. 60, no. 2, pp. 615-624, 2017

Authors: Canevelli, Marco | Zaccaria, Valerio | Lacorte, Eleonora | Cova, Ilaria | Remoli, Giulia | Bacigalupo, Ilaria | Cascini, Silvia | Bargagli, Anna Maria | Pomati, Simone | Pantoni, Leonardo | Vanacore, Nicola

Article Type: Research Article

Abstract: Background: The construct of mild cognitive impairment (MCI) is triggering growing clinical and research interest. The detection of MCI may be affected by diverse ethno-cultural determinants possibly influencing the personal and social perception of the individual cognitive functioning as well as the reliability of objective cognitive assessment. These challenges may acquire special relevance in subjects with a migration background and composing ethnic minority groups. Objective: The present study is aimed at providing an estimate of the number of MCI cases occurring in the migrant population living in the extended European Union (EU) in 2018. Methods: The number of MCI cases …in older migrants living in Europe and in each of the 32 considered countries was estimated by multiplying the number of migrants, provided by Eurostat, with the age-specific prevalence rates, derived by the harmonized data produced by the COSMIC collaboration and based on different operational definitions of MCI. Results: Nearly 686,000 cases of MCI were estimated in the extended EU by applying age-specific prevalence rates based on the International Working Group criteria. Higher figures were obtained when the Clinical Dementia Rating- and the Mini Mental State Examination-based criteria were applied. The proportion of MCI cases in migrant subjects ranged from 1.1% (Romania) to 54.1% (Liechtenstein) (median: 8.4%; IQR: 4.7%–14.2%). Conclusions: MCI represents and will increasingly constitute a relevant issue in the migrant population living in Europe. The present data reinforce the need of developing approaches and models of care that may be diversity-sensitive and inclusive for a culturally variegated population. Show more

Keywords: Cognitive disorders, health disparities, migration, mild cognitive impairment, neuroepidemiology

DOI: 10.3233/JAD-191012

Citation: Journal of Alzheimer's Disease, vol. 73, no. 2, pp. 715-721, 2020

Authors: Poggesi, Anna | Salvadori, Emilia | Valenti, Raffaella | Nannucci, Serena | Ciolli, Laura | Pescini, Francesca | Pasi, Marco | Fierini, Fabio | Donnini, Ida | Marini, Sandro | Chiti, Guido | Rinnoci, Valentina | Inzitari, Domenico | Pantoni, Leonardo

Article Type: Research Article

Abstract: Background and objective: Services dedicated to patients with cognitive and behavioral consequences of cerebrovascular diseases are not well established. In this paper, we report on the general organization of such a service (the Florence VAS-COG Clinic) after 9 years of activity, updating a previous work related to the first 5 years. Methods: The Florence VAS-COG clinic, started in 2006, is an outpatient service dedicated to the assessment and follow-up of patients with cerebrovascular diseases and related cognitive, psychiatric, and behavioral disturbances. The staff involved in the clinic is composed of certified neurologists, one neuropsychologist, and neurology residents. The diagnostic protocol …includes detailed personal and family history, general and neurologic examinations, and functional, neuropsychological, and neuroimaging assessment. After this work-up, comprehensive diagnoses are made. Results: From January 2006 to March 2014, 600 patients (mean age 67.3 years ± 13.9; 52% females) have been evaluated in the clinic. Cognitive impairment, including mild cognitive impairment and dementia, mainly of vascular origin, was the most common (36.4%) diagnostic category, followed by suspected or confirmed familial micro-angiopathy (35.8%). Compared to the first years of activity, we are now facing the need of augmenting the number of visits due to increasing request and to better implement the multidisciplinarity of the team. Efforts are currently directed towards the definition of management protocols in pharmacological and non-pharmacological strategies. Conclusions: The establishment of a VAS-COG clinic represents an important step for the appreciation of the patient clinical needs and for the implementation of screening, diagnostic, and treatment options in the field of the neuropsychiatric consequences of cerebrovascular diseases. Show more

Keywords: Dementia, mild cognitive impairment, outpatient clinic, post-stroke aphasia, post-stroke depression, small vessel disease, stroke, vascular cognitive impairment

DOI: 10.3233/JAD-141569

Citation: Journal of Alzheimer's Disease, vol. 42, no. s4, pp. S453-S461, 2014

Authors: Valenti, Raffaella | Charidimou, Andreas | Xiong, Li | Boulouis, Gregoire | Fotiadis, Panagiotis | Ayres, Alison | Riley, Grace | Kuijf, Hugo J. | Reijmer, Yael D. | Pantoni, Leonardo | Gurol, M. Edip | Davidsdottir, Sigurros | Greenberg, Steven M. | Viswanathan, Anand

Article Type: Short Communication

Abstract: Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23% on Benton Facial Recognition Test [BFRT] and 13.6% on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds. This pilot study highlights the presence of visual-processing deficits in CAA. The impairment could be related to global disease severity in addition to local brain injury.

Keywords: Cerebral amyloid angiopathy, neuroimaging markers, neuropsychological assessment, visuospatial functioning

DOI: 10.3233/JAD-160927

Citation: Journal of Alzheimer's Disease, vol. 56, no. 4, pp. 1223-1227, 2017

Authors: Verdelho, Ana | Madureira, Sofia | Moleiro, Carla | Santos, Catarina O. | Ferro, José M. | Erkinjuntti, Timo | Poggesi, Anna | Pantoni, Leonardo | Fazekas, Franz | Scheltens, Philip | Waldemar, Gunhild | Wallin, Anders | Inzitari, Domenico | and on behalf of the LADIS Study

Article Type: Research Article

Abstract: Memory complaints are frequent in the elderly but its implications in cognition over time remain a controversial issue. Our objective was to evaluate the risk of self perceived memory complaints in the evolution for future dementia. The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates the impact of white matter changes (WMC) on the transition of independent elderly subjects into disability. Independent elderly were enrolled due to the presence of WMC. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and a neuropsychological battery. Dementia and subtypes of dementia were classified. Self perceived memory complaints in …independent elderly were collected during the interview. MRI was performed at entry and at the end of the study. 639 subjects were included (74.1 ± 5 years old, 55% women, 9.6 ± 3.8 years of schooling). At end of follow-up, 90 patients were demented (vascular dementia, 54; Alzheimer's disease (AD) and AD with vascular component, 34; frontotemporal dementia, 2). Using Cox regression analysis, we found that self perceived memory complaints were a strong predictor of AD and AD with vascular component during the follow-up (β = 2.7, p = 0.008; HR = 15.5, CI 95% [2.04, 117.6]), independently of other confounders, namely depressive symptoms, WMC severity, medial temporal lobe atrophy, and global cognition status at baseline. Self perceived memory complaints did not predict vascular dementia. In the LADIS study, self perceived memory complaints predicted AD but not vascular dementia in elderly subjects with WMC living independently. Show more

Keywords: Aging, Alzheimer's disease, dementia, memory complaints, white matter changes

DOI: 10.3233/JAD-2011-110494

Citation: Journal of Alzheimer's Disease, vol. 27, no. 3, pp. 491-498, 2011

Authors: Bonavita, Vincenzo | Padovani, Alessandro | Bruni, Amalia | Pantoni, Leonardo | Caltagirone, Carlo | Parnetti, Lucilla | Clerici, Francesca | Perani, Daniela | Di Luca, Monica | Sorbi, Sandro | Forloni, Gianluigi | Tagliavini, Francesco | Frisoni, Giovanni | Tempini, Marilu Gorno | Mariani, Claudio | Venneri, Annalena | Musicco, Massimo

Article Type: Abstract

Abstract: Abstracts of the IX Congresso Sindem Italian Association for the study of Dementia linked to the Italian Neurological Society (SIN) Firenze, Palazzo dei Congressi, Villa Vittoria March 13–15, 2014 Comitato Scientifico: Vincenzo Bonavita, Alessandro Padovani, Amalia Bruni, Leonardo Pantoni, Carlo Caltagirone, Lucilla Parnetti, Francesca Clerici, Daniela Perani, Monica Di Luca, Sandro Sorbi, Gianluigi Forloni, Francesco Tagliavini, Giovanni Frisoni, Marilu Gorno Tempini, Claudio Mariani, Annalena Venneri, Massimo Musicco

DOI: 10.3233/JAD-149999

Citation: Journal of Alzheimer's Disease, vol. 41, no. s2, pp. S1-S68, 2014

Authors: Cascini, Silvia | Canevelli, Marco | Agabiti, Nera | Angelici, Laura | Davoli, Marina | Bacigalupo, Ilaria | Cova, Ilaria | Vanacore, Nicola | Pomati, Simone | Pantoni, Leonardo | Acampora, Anna | Bargagli, Anna Maria | Ancidoni, Antonio | Bacigalupo, Ilaria | Bellomo, Guido | Canevelli, Marco | Giusti, Angela | Lacorte, Eleonora | Palazzesi, Ilaria | Piscopo, Paola | Porrello, Mariacristina | Sciancalepore, Francesco | Vanacore, Nicola | Zambri, Francesca | Salvi, Emanuela | Acampora, Anna | Agabiti, Nera | Angelici, Laura | Bargagli, Anna Maria | Cascini, Silvia | Davoli, Marina | Cova, Ilaria | Maestri, Giorgia | Nicotra, Alessia | Pantoni, Leonardo | Pomati, Simone | Bruno, Giuseppe | Zaccaria, Valerio | Remoli, Giulia | Valletta, Martina | Di Blasio, Norina | De Fiore, Luca | Visco, Caterina

Article Type: Research Article

Abstract: Background: A crucial step for planning effective public health policies for migrants with dementia is the collection of data on the local dimensions of the phenomenon and patients’ characteristics. Objective: This study aimed to identify and characterize migrants with dementia in the Lazio region using health administrative databases. Methods: Residents with dementia aged 50 years or older, living in the Lazio region as of December 31, 2018, were identified using a validated algorithm based on hospital discharge(s), claims for antidementia drugs, and co-payment exemption for dementia. Migrants were defined as people born abroad and grouped in migrants from High Migratory …Pressure Countries (HMPCs) and Highly Developed Countries (HDCs). Overall and age-specific prevalence rates were estimated in native- and foreign-born patients. Results: Dementia was ascertained in 38,460 residents. Among them, 37,280 (96.9%) were born in Italy, 337 (0.9%) were migrants from HDCs, and 843 (2.2%) from HMPCs. Dementia prevalence was higher among natives (1.15%, 95% CI 1.14–1.16) relative to migrants from HDCs (0.60%, 95% CI 0.54–0.67) and HMPCs (0.29%, 95% CI 0.27–0.31). The prevalence of comorbidities did not differ between groups. Migrants with dementia had a lower likelihood of receiving antidementia treatments compared with natives (51.6% in migrants from HDCs, 49.3% in migrants from HMPCs, and 53.5% among Italians). Conclusion: Routinely collected data in healthcare administrative databases can support the identification of migrants with dementia. Migrants exhibited a lower age-standardized prevalence of registered dementia and lower access to dedicated treatments than Italians. These findings are suggestive of underdiagnosis and undertreatment of dementia in migrants. Show more

Keywords: Access to care, dementia, diversity, migrants, record linkage

DOI: 10.3233/JAD-221146

Citation: Journal of Alzheimer's Disease, vol. 92, no. 3, pp. 843-852, 2023