Abstract: Alterations of serotonin type 4 receptor levels are linked to mood disorders and cognitive deficits in several conditions. However, few studies have investigated 5-HT4 R alterations in movement disorders. We wondered whether striatal 5-HT4 R expression is altered in experimental parkinsonism. We used a brain bank tissue from a rat and a macaque model of Parkinson’s disease (PD). We then investigated its in vivo PET imaging regulation in a cohort of macaques. Dopaminergic depletion increases striatal 5-HT4 R in the two models, further augmented after dyskinesia-inducing L-Dopa. Pending confirmation in PD patients, the 5-HT4 R might offer a therapeutic target…for dampening PD’s symptoms.
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Keywords: Parkinson’s disease, serotonin, PET imaging, immunohistochemistry, experimental animal models, L-Dopa, movement disorders, parkinsonism, dyskinesia