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Authors: González Cordero, Elisa Marina | Cuevas-Budhart, Miguel Angel | Pérez Morán, Diana | Trejo Villeda, Miguel Angel | Gomez-del-Pulgar Gª-Madrid, Mercedes

Article Type: Systematic Review

Abstract: Background: In recent years, scientific research on the gut microbiota and their relationship with some diseases, including neurological ones, has notably increased. As a result of these investigations, the so-called gut-brain axis arises. Despite its influence on the evolution and development of cognitive impairment, the gut-brain axis is little defined and demonstrated. Objective: To provide the best scientific evidence available on the relationship between the gut microbiota and Alzheimer’s disease. Method: Systematic and narrative review of the information generated in the last 5 years in national and international databases, in English and Spanish. Results: Eight observational studies were selected, carried …out in humans and, therefore, suitable for inclusion in this review. Conclusion: The results of these studies support the hypothesis that there is a relationship between the gut microbiota and cognitive disorders through the gut-brain axis. However, today, there is a substantial lack of human studies, especially clinical trials, which makes it difficult to formulate clinical recommendations on this topic. Show more

Keywords: Alzheimer’s disease, gut-brain axis, gut microbiome, microbiota, Parkinson’s disease

DOI: 10.3233/JAD-215224

Citation: Journal of Alzheimer's Disease, vol. 87, no. 2, pp. 519-528, 2022