Your search for: 'author:("Kapoor, Arunima")' has returned 2 results. (0.008s) Save search

Authors: Marshall, Anisa J. | Gaubert, Aimee | Kapoor, Arunima | Tan, Alick | McIntosh, Elissa | Jang, Jung Yun | Yew, Belinda | Ho, Jean K. | Blanken, Anna E. | Dutt, Shubir | Sible, Isabel J. | Li, Yanrong | Rodgers, Kathleen | Nation, Daniel A.

Article Type: Research Article

Abstract: Background: Depletion of blood-derived progenitor cells, including so called “early endothelial progenitor cells”, has been observed in individuals with early stage Alzheimer’s disease relative to matched older control subjects. These findings could implicate the loss of angiogenic support from hematopoietic progenitors or endothelial progenitors in cognitive dysfunction. Objective: To investigate links between progenitor cell proliferation and mild levels of cognitive dysfunction. Methods: We conducted in vitro studies of blood-derived progenitor cells using blood samples from sixty-five older adults who were free of stroke or dementia. Peripheral blood mononuclear cells from venous blood samples were cultured in CFU-Hill media and the …number of colony forming units were counted after 5 days in vitro . Neuropsychological testing was administered to all participants. Results: Fewer colony forming units were observed in samples from older adults with a Clinical Dementia Rating global score of 0.5 versus 0. Older adults whose samples developed fewer colony forming units exhibited worse performance on neuropsychological measures of memory, executive functioning, and language ability. Conclusion: These data suggest blood progenitors may represent a vascular resilience marker related to cognitive dysfunction in older adults. Show more

Keywords: Alzheimer’s disease, cognitive dysfunction, progenitor cells, vascular resilience

DOI: 10.3233/JAD-220269

Citation: Journal of Alzheimer's Disease, vol. 93, no. 3, pp. 1041-1050, 2023

Authors: Zinman, Julia | Kapoor, Arunima | Si, Kevin | Sujanthan, Sajeevan | Southwell, Alisia | Cayley, Megan L. | Sicard, Michelle N. | Lien, Karen | Murray, Brian J. | Lanctôt, Krista | Herrmann, Nathan | Dowlatshahi, Dar | Sahlas, Demetrios J. | Saposnik, Gustavo | Mandzia, Jennifer L. | Casaubon, Leanne K. | Hassan, Ayman | Perez, Yael | Swartz, Richard H.

Article Type: Short Communication

Abstract: While women have greater incidence of dementia, men have higher prevalence of vascular risk factors. This study examined sex differences in risk of screening positive for cognitive impairment after stroke. Ischemic stroke/TIA patients (N = 5969) participated in this prospective, multi-centered study, which screened for cognitive impairment using a validated brief screen. Men showed a higher risk of screening positive for cognitive impairment after adjusting for age, education, stroke severity, and vascular risk factors, suggesting that other factors may be contributing to increased risk among men (OR = 1.34, CI 95% [1.16, 1.55], p  < 0.001). The effect of sex on cognitive impairment after stroke …warrants further attention. Show more

Keywords: Alzheimer’s disease, cognitive impairment, sex difference, stroke, transient ischemic attack

DOI: 10.3233/JAD-230021

Citation: Journal of Alzheimer's Disease, vol. 94, no. 1, pp. 89-94, 2023