Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species
- PMID: 9681984
- DOI: 10.1006/abbi.1998.0755
Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species
Abstract
Analytical and immunological methodologies and occasionally both methodologies have been applied to detect and quantify 3-nitrotyrosine in almost every major organ system. In certain diseases increased levels of 3-nitrotyrosine have been correlated with elevated levels of other indices of oxidative stress. Numerous reports have established that nitration is a biological process derived from the biochemical interaction of nitric oxide or nitric oxide-derived secondary products with reactive oxygen species. This article addresses critical issues regarding this biological process, namely the biochemical pathways for nitration of tyrosine residues in vivo, potential protein targets, and pathophysiological consequences of protein tyrosine nitration.
Copyright 1998 Academic Press.
Similar articles
-
Inactivation of glutathione S-transferases by nitric oxide-derived oxidants: exploring a role for tyrosine nitration.Arch Biochem Biophys. 2001 Oct 15;394(2):216-28. doi: 10.1006/abbi.2001.2532. Arch Biochem Biophys. 2001. PMID: 11594736
-
Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase.Free Radic Biol Med. 2006 Jun 1;40(11):1903-13. doi: 10.1016/j.freeradbiomed.2005.09.006. Epub 2005 Nov 15. Free Radic Biol Med. 2006. PMID: 16716892
-
Protein tyrosine nitration--an update.Arch Biochem Biophys. 2009 Apr 15;484(2):117-21. doi: 10.1016/j.abb.2008.10.034. Epub 2008 Oct 30. Arch Biochem Biophys. 2009. PMID: 19007743 Review.
-
Biochemistry of protein tyrosine nitration in cardiovascular pathology.Cardiovasc Res. 2007 Jul 15;75(2):291-302. doi: 10.1016/j.cardiores.2007.04.024. Epub 2007 May 3. Cardiovasc Res. 2007. PMID: 17544386 Review.
-
Glycyrrhizae Radix attenuates peroxynitrite-induced renal oxidative damage through inhibition of protein nitration.Free Radic Res. 2005 Feb;39(2):203-11. doi: 10.1080/10715760400027888. Free Radic Res. 2005. PMID: 15763968
Cited by
-
Positron Emission Tomography with [18F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy.Int J Mol Sci. 2024 May 1;25(9):4943. doi: 10.3390/ijms25094943. Int J Mol Sci. 2024. PMID: 38732162 Free PMC article.
-
Nitroproteomics is instrumental for stratification and targeted treatments of astrocytoma patients: expert recommendations for advanced 3PM approach with improved individual outcomes.EPMA J. 2023 Dec 6;14(4):673-696. doi: 10.1007/s13167-023-00348-y. eCollection 2023 Dec. EPMA J. 2023. PMID: 38094577 Review.
-
Enlarging the scenario of site directed 19F labeling for NMR spectroscopy of biomolecules.Sci Rep. 2023 Dec 12;13(1):22017. doi: 10.1038/s41598-023-49247-2. Sci Rep. 2023. PMID: 38086881 Free PMC article.
-
Age-related nitration/dysfunction of myogenic stem cell activator HGF.Aging Cell. 2024 Feb;23(2):e14041. doi: 10.1111/acel.14041. Epub 2023 Nov 20. Aging Cell. 2024. PMID: 37985931 Free PMC article.
-
Saying no to SARS-CoV-2: the potential of nitric oxide in the treatment of COVID-19 pneumonia.Med Gas Res. 2024 Apr-Jun;14(2):39-47. doi: 10.4103/2045-9912.385414. Med Gas Res. 2024. PMID: 37929506 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources