Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
- PMID: 21075313
- PMCID: PMC3031091
- DOI: 10.1016/j.ccr.2010.10.012
Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
Abstract
We investigated whether melanoma is hierarchically organized into phenotypically distinct subpopulations of tumorigenic and nontumorigenic cells or whether most melanoma cells retain tumorigenic capacity, irrespective of their phenotype. We found 28% of single melanoma cells obtained directly from patients formed tumors in NOD/SCID IL2Rγ(null) mice. All stage II, III, and IV melanomas obtained directly from patients had common tumorigenic cells. All tumorigenic cells appeared to have unlimited tumorigenic capacity on serial transplantation. We were unable to find any large subpopulation of melanoma cells that lacked tumorigenic potential. None of 22 heterogeneously expressed markers, including CD271 and ABCB5, enriched tumorigenic cells. Some melanomas metastasized in mice, irrespective of whether they arose from CD271(-) or CD271(+) cells. Many markers appeared to be reversibly expressed by tumorigenic melanoma cells.
Copyright © 2010 Elsevier Inc. All rights reserved.
Figures
Similar articles
-
Identification of cells initiating human melanomas.Nature. 2008 Jan 17;451(7176):345-9. doi: 10.1038/nature06489. Nature. 2008. PMID: 18202660 Free PMC article.
-
CD271 is an imperfect marker for melanoma initiating cells.Oncotarget. 2014 Jul 30;5(14):5272-83. doi: 10.18632/oncotarget.1967. Oncotarget. 2014. PMID: 25105565 Free PMC article.
-
Isolation of tumorigenic circulating melanoma cells.Biochem Biophys Res Commun. 2010 Nov 26;402(4):711-7. doi: 10.1016/j.bbrc.2010.10.091. Epub 2010 Oct 25. Biochem Biophys Res Commun. 2010. PMID: 20977885 Free PMC article.
-
Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma.Pigment Cell Melanoma Res. 2009 Dec;22(6):740-9. doi: 10.1111/j.1755-148X.2009.00630.x. Epub 2009 Aug 29. Pigment Cell Melanoma Res. 2009. PMID: 19725928 Free PMC article. Review.
-
Stem cells and targeted approaches to melanoma cure.Mol Aspects Med. 2014 Oct;39:33-49. doi: 10.1016/j.mam.2013.10.003. Epub 2013 Oct 19. Mol Aspects Med. 2014. PMID: 24145241 Free PMC article. Review.
Cited by
-
The uniqueness of ABCB5 as a full transporter ABCB5FL and a half-transporter-like ABCB5β.Cancer Drug Resist. 2024 Aug 7;7:29. doi: 10.20517/cdr.2024.56. eCollection 2024. Cancer Drug Resist. 2024. PMID: 39267923 Free PMC article. Review.
-
Unveiling the Dynamic Interplay between Cancer Stem Cells and the Tumor Microenvironment in Melanoma: Implications for Novel Therapeutic Strategies.Cancers (Basel). 2024 Aug 16;16(16):2861. doi: 10.3390/cancers16162861. Cancers (Basel). 2024. PMID: 39199632 Free PMC article. Review.
-
A general algorithm for consensus 3D cell segmentation from 2D segmented stacks.bioRxiv [Preprint]. 2024 May 6:2024.05.03.592249. doi: 10.1101/2024.05.03.592249. bioRxiv. 2024. PMID: 38766074 Free PMC article. Preprint.
-
Plasticity and resistance of cancer stem cells as a challenge for innovative anticancer therapies - do we know enough to overcome this?EXCLI J. 2024 Feb 29;23:335-355. doi: 10.17179/excli2024-6972. eCollection 2024. EXCLI J. 2024. PMID: 38655094 Free PMC article. Review.
-
Cancer Stem Cells from Definition to Detection and Targeted Drugs.Int J Mol Sci. 2024 Mar 31;25(7):3903. doi: 10.3390/ijms25073903. Int J Mol Sci. 2024. PMID: 38612718 Free PMC article. Review.
References
-
- Agliano A, Martin-Padura I, Mancuso P, Marighetti P, Rabascio C, Pruneri G, Shultz LD, Bertolini F. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. International Journal of Cancer. 2008;123:2222–2227. - PubMed
-
- Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Medicine. 1997;3:730–737. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical