Frank Luptow was born on 20 November 1905 in Markesan, Wisconsin, United States. He died on 21 September 1952 in Lakewood Speedway, Atlanta, Georgia, United States.
He was an American racing driver. He attempted to qualify for the 1952 Indianapolis 500, but failed to do so. This was his only Indianapolis 500 participation, as he was killed a few months later in a racing accident.